{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T03:19:31Z","timestamp":1776309571811,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Long noncoding RNA small nucleolar RNA host gene 16 (lnc\u2010SNHG16) regulates sepsis\u2010induced acute lung injury and inflammation, which is involved in the pathophysiology of acute respiratory distress syndrome (ARDS). The present study intended to explore the role of lnc\u2010SNHG16 as a potential biomarker indicating ARDS risk, disease severity, inflammation, and mortality in sepsis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Peripheral blood mononuclear cell (PBMC) samples were collected from 160 sepsis patients within 24\u2009hours after admission and 30 healthy controls (HCs). Then, lnc\u2010SNHG16 in PBMCs was detected by reverse transcription\u2010quantitative polymerase chain reaction. Sepsis patients were followed up until death or up to 28\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>lnc\u2010SNHG16 was declined in sepsis patients compared with HCs (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The incidence of ARDS was 27.5% among sepsis patients; meanwhile, sepsis patients with ARDS had higher mortality than those without ARDS (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Furthermore, lnc\u2010SNHG16 was declined in sepsis patients with ARDS compared to those without ARDS (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001); besides, higher lnc\u2010SNHG16 was independently correlated with declined ARDS occurrence in sepsis patients (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001), while primary respiratory infection and higher CRP were independently correlated with elevated ARDS occurrence in sepsis patients (both <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Moreover, a negative correlation was found in lnc\u2010SNHG16 with history of diabetes, history of chronic obstructive pulmonary disease, and APACHE II and SOFA scores (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Additionally, lnc\u2010SNHG16 was declined in sepsis deaths compared with survivors (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.002), while it was not independently linked with sepsis mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>lnc\u2010SNHG16 correlates with lower ARDS occurrence and better prognosis in sepsis patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24516","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T16:34:57Z","timestamp":1653669297000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Correlation of small nucleolar <scp>RNA<\/scp> host gene 16 with acute respiratory distress syndrome occurrence and prognosis in sepsis patients"],"prefix":"10.1002","volume":"36","author":[{"given":"Chengju","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Zhongshan Hospital Affiliated to Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinghe","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit Zhongshan Hospital Affiliated to Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9586-5298","authenticated-orcid":false,"given":"Fuyun","family":"He","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit Zhongshan Hospital Affiliated to Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20200830"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-06010-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1683996"},{"issue":"4","key":"e_1_2_8_5_1","first-page":"437","article-title":"Understanding the pathophysiology of typical acute respiratory distress syndrome and severe COVID\u201019","volume":"16","author":"Ball L","year":"2022","journal-title":"Expert Rev Respir Med"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885066619855021"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S231630"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-021-01552-0"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.05.008"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/bbb\/zbab016"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.02.043"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5589089"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2022.2026861"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S186923"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.3.7509706"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e3182a64682"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201004-0549OC"},{"issue":"2","key":"e_1_2_8_19_1","first-page":"31","article-title":"microRNA\u201023a\u20105p acts as a potential biomarker for sepsis\u2010induced acute respiratory distress syndrome in early stage","volume":"62","author":"Liu S","year":"2016","journal-title":"Cell Mol Biol (Noisy\u2010le\u2010Grand)"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-06248-8"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2018.06.012"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-013-0375-y"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/09603271211035665"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0000000000000958"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2018_180720N504"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174601"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13049-019-0609-3"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.5644\/ama2006-124.165"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.24516","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcla.24516","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.24516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T02:14:25Z","timestamp":1692756865000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.24516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,27]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1002\/jcla.24516"],"URL":"https:\/\/doi.org\/10.1002\/jcla.24516","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,27]]},"assertion":[{"value":"2022-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e24516"}}