{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T09:42:20Z","timestamp":1779183740436,"version":"3.51.4"},"reference-count":54,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T00:00:00Z","timestamp":1654473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Atherosclerosis plays an important role in the pathophysiology of acute coronary syndrome (ACS). CD36 is a scavenger receptor involved in lipid metabolism. Some single\u2010nucleotide variants in the non\u2010coding region could indirectly alter the expression and the function of the protein.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to investigate the gene and protein expression associated with <jats:italic>CD36<\/jats:italic> variants (rs1194182;C\u2009&gt;\u2009G; rs1049654;C\u2009&gt;\u2009A, rs1334512;G\u2009&gt;\u2009T, and rs3211892;G\u2009&gt;\u2009A) in ACS patients from the western Mexican population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 310 ACS patients and 308 subjects in the control group (CG). Genotyping was determined by TaqMan SNP genotyping assays. CD36 expression at the mRNA level was quantified by TaqMan gene expression assays. Soluble CD36 (sCD36) was measured by enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We show that rs1194182G\u2009&gt;\u2009C variant provides a protective effect with a 1.7\u2010fold lower susceptibility to develop ACS (<jats:italic>p<\/jats:italic> \u00a0=\u00a00.03); however, this association was masked by diabetes and dyslipidemia. We observed a higher sCD36 concentration in patient with ST\u2010segment elevation myocardial infarction (STEMI) compared with patients with unstable angina (UA) (<jats:italic>p<\/jats:italic> \u00a0=\u00a00.038). Likewise, in diabetic patients versus non\u2010diabetic (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). We observed in patients an increase in <jats:italic>CD36<\/jats:italic> mRNA expression (1.91 times higher) than in the CG (<jats:italic>p<\/jats:italic> \u00a0=\u00a00.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The rs1194182 seems to be associated with diabetes in a risky manner, in ACS patients and protective for dyslipidemia in both groups. The concentration of sCD36 seems to be associated with the clinical spectrum of the ACS patients and the presence of diabetes, since patients with STEMI present significantly elevated level compared with UA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24529","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T15:35:31Z","timestamp":1654529731000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Genetic variants, gene expression, and soluble <scp>CD36<\/scp> analysis in acute coronary syndrome: Differential protein concentration between <scp>ST<\/scp>\u2010segment elevation myocardial infarction and unstable angina"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2653-0301","authenticated-orcid":false,"given":"Brenda","family":"Parra\u2010Reyna","sequence":"first","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Ciencias Biom\u00e9dicas 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M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7564-4877","authenticated-orcid":false,"given":"Texali Candelaria","family":"Garc\u00eda\u2010Gardu\u00f1o","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Ciencias Biom\u00e9dicas Universidad de Guadalajara  Guadalajara Mexico"},{"name":"Doctorado en Gen\u00e9tica Humana Universidad de Guadalajara  Guadalajara M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3640-4870","authenticated-orcid":false,"given":"Diana Emilia","family":"Mart\u00ednez\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Ciencias Biom\u00e9dicas Universidad de Guadalajara  Guadalajara Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer J.","family":"Jacobo\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Servicio de 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