{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T10:36:23Z","timestamp":1782729383888,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T00:00:00Z","timestamp":1657238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>JKAP modifies T\u2010cell immune response and inflammation, also involves in cardia\u2010cerebrovascular disease etiology. This study intended to explore JKAP's relation with T\u2010helper 1 (Th1), T\u2010helper 17 (Th17) cell levels, clinical properties, and recurrence\u2010free survival (RFS) in acute ischemic stroke (AIS) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 155 AIS patients were analyzed. Serum JKAP, interferon\u2010gamma (IFN\u2010\u03b3), and interleukin\u201017A (IL\u201017A) were detected by ELISA; then blood Th1 and Th17 cells were quantified by flow cytometry. Besides, 30 healthy subjects were enrolled as controls to detect JKAP, Th1, and Th17 cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>JKAP level was lower (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), Th1 cells were not differed (<jats:italic>p\u2009=<\/jats:italic>\u00a00.068), but Th17 cells were elevated in AIS patients versus controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Meanwhile, JKAP was negatively correlated with Th1 cells (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.038), Th17 cells (<jats:italic>P<\/jats:italic>&lt;0.001), IFN\u2010\u03b3 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.002), and IL\u201017A (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001) in AIS patients. JKAP was negatively associated with the National Institutes of Health Stroke Scale (NIHSS) score (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001), but Th17 cells (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001), IFN\u2010\u03b3 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.035), and IL\u201017A (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.008) levels were positively associated with NIHSS score. Additionally, accumulating RFS was numerically longer in patients with JKAP Quantile (Q) 4 than patients with JKAP Q1\u2013Q3 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.068), and numerically better in patients with JKAP Q3\u2013Q4 than patients with JKAP Q1\u2013Q2 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.069), but without statistical significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>JKAP correlates with lower Th1 and Th17 cell percentages as well as milder disease severity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24535","type":"journal-article","created":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T06:59:32Z","timestamp":1657349972000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["JNK pathway\u2010associated phosphatase in acute ischemic stroke patients: Its correlation with T helper cells, clinical properties, and recurrence risk"],"prefix":"10.1002","volume":"36","author":[{"given":"Ping","family":"Zhao","sequence":"first","affiliation":[{"name":"Second Department of Neurology HanDan Central Hospital  Handan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyong","family":"Huo","sequence":"additional","affiliation":[{"name":"Second Department of Neurology HanDan Central Hospital  Handan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntao","family":"Li","sequence":"additional","affiliation":[{"name":"Second Department of Neurology HanDan Central Hospital  Handan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Second Department of Neurology HanDan Central Hospital  Handan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Liu","sequence":"additional","affiliation":[{"name":"Second Department of Neurology HanDan Central Hospital 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