{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:49:45Z","timestamp":1765828185697,"version":"3.41.2"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,6,12]],"date-time":"2022-06-12T00:00:00Z","timestamp":1654992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2017A030313669"],"award-info":[{"award-number":["2017A030313669"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Obstructive sleep apnea (OSA) has a high incidence and is harmful to health. It is characterized by repeated collapse of the upper airway. However, the mechanism underlying upper airway collapse is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with OSA and chronic tonsillitis were studied. Pathological changes in palatopharyngeus muscle were detected. The expression of peroxisome proliferator\u2010activated receptor\u2010\u03b3 co\u2010activator\u20101\u03b1 (PGC\u20101\u03b1) and nuclear respiratory factor\u20101 (NRF\u20101) in muscles was detected by PCR and Western blotting. Immunofluorescence staining was used to detect the expression of type I and type II myofibril.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The structure of the palatopharyngeus muscle was changed, and the expression of PGC\u20101\u03b1 and NRF\u20101 was decreased in the OSA group compared with that in the control group. The expression of PGC\u20101\u03b1, NRF\u20101, and type I myofibril in C2C12 myoblasts was decreased by intermittent hypoxia exposure. The expression of type I myofibril was decreased when knocking down PGC\u20101\u03b1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>OSA patients exhibited pathological damage in palatopharyngeus muscle. PGC\u20101\u03b1 was involved in the fiber type conversion in palatopharyngeus muscle caused by intermittent hypoxia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24551","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T03:59:18Z","timestamp":1655092758000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Role of <scp>PGC<\/scp>\u20101\u03b1 in fiber type conversion in the palatopharyngeus muscle of <scp>OSA<\/scp> patients"],"prefix":"10.1002","volume":"36","author":[{"given":"Ling","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guang zhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongqing","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck, Sun Yat\u2010sen Memorial 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