{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:49:24Z","timestamp":1792028964734,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T00:00:00Z","timestamp":1656201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Long noncoding RNA (lncRNA) cancer susceptibility candidate gene 2 (CASC2) inhibits inflammation and multi\u2010organ dysfunction in various ways. The present study was intended to explore the potency of blood lncRNA CASC2 as a biomarker for sepsis management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Totally, 184 sepsis patients and 30 healthy controls were enrolled. The reverse transcription\u2010quantitative polymerase chain reaction was used to detect lncRNA CASC2 expression in peripheral blood mononuclear cell samples from the subjects. Mortality during 28\u2009days was recorded in sepsis patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LncRNA CASC2 was decreased in sepsis patients [median (interquartile range [IQR]): 0.473 (0.241\u20130.773)] by comparison to healthy controls [median (IQR): 1.019 (0.676\u20131.685)] (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In sepsis patients, lncRNA CASC2 was negatively correlated with Acute Physiology and Chronic Health Evaluation II (APACHE II) (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001), Sequential Organ Failure Assessment (SOFA) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), SOFA\u2010respiratory system (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.010), SOFA\u2010coagulation (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.020), SOFA\u2010liver (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.019), and SOFA\u2010renal (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.010) scores, but was not related to SOFA\u2010nervous (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.466) and SOFA\u2010cardio vascular system (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.059) scores. Additionally, lncRNA CASC2 was negatively related to tumor necrosis factor\u2010\u03b1 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.024), interleukin (IL)\u20101\u03b2 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.013), and IL\u201017A (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.002), but was not linked to IL\u20106 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.112) or IL\u201010 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.074). Furthermore, lncRNA CASC2 was lower in sepsis deaths [median (IQR): 0.286 (0.166\u20130.475)] than in survivors [median (IQR): 0.534 (0.296\u20130.811)] (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Simultaneously, Kaplan\u2013Meier (KM) curve analysis also observed that lncRNA CASC2 was inversely related to accumulating mortality in sepsis patients (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.003). While lncRNA CASC2 could independently predict lower mortality risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Circulating lncRNA CASC2 inadequacy indicates the release of inflammatory cytokines, severe multi\u2010organ injuries, and increased mortality in sepsis patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24569","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T04:29:56Z","timestamp":1656304196000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Potential of circulating <scp>lncRNA CASC2<\/scp> as a biomarker in reflecting the inflammatory cytokines, multi\u2010organ dysfunction, disease severity, and mortality in sepsis patients"],"prefix":"10.1002","volume":"36","author":[{"given":"Rui","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine Cangzhou Central Hospital  Cangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinglin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Cangzhou Central Hospital  Cangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Cangzhou Central Hospital  Cangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Cangzhou Central Hospital  Cangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Cangzhou Medical College  Cangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caihong","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Cangzhou Medical College  Cangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Cangzhou Central Hospital  Cangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Cangzhou Central Hospital  Cangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Cangzhou Central Hospital  Cangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingchun","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Cangzhou Central Hospital  Cangzhou 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