{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:56:40Z","timestamp":1753869400977,"version":"3.41.2"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T00:00:00Z","timestamp":1656201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370615","81600097","82070120"],"award-info":[{"award-number":["81370615","81600097","82070120"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To discuss the clinical features of a patient with hereditary hemorrhagic telangiectasia (HHT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The clinical data of one patient with HHT are retrospectively analysed. In addition, we review the relevant literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A 32\u2010year\u2010old male patient was admitted to the hematology outpatient department of our hospital and presented with intermittent epistaxis for 24\u2009years. In recent years, he was diagnosed with iron deficiency anemia. The nasal endoscopic examination showed telangiectasia at the front of the right\u2010middle turbinate and the left nasal cavity. He had ENG genetic mutation positivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with HHT may suffer from many complications, including bleeding, anemia, iron deficiency, and high\u2010output heart failure. These patients may have telangiectasias and arteriovenous malformations in various organs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24571","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T05:15:47Z","timestamp":1656306947000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A case of hereditary hemorrhagic telangiectasia and literature review"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1363-7484","authenticated-orcid":false,"given":"Yu","family":"Han","sequence":"first","affiliation":[{"name":"Department of Hematology Huaihe Hospital of Henan University  Kaifeng China"},{"name":"Department of Hematology, Henan Cancer Hospital The Affiliated Cancer Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingjie","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Hematology, Henan Cancer Hospital The Affiliated Cancer Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengjuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology, Henan Cancer Hospital The Affiliated Cancer Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuewen","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Hematology, Henan Cancer Hospital The Affiliated Cancer Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology, Henan Cancer Hospital The Affiliated Cancer Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3182136d32"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.04.028"},{"key":"e_1_2_7_4_1","first-page":"818","article-title":"Patients with hereditary hemorrhagic telangiectasia have increased plasma levels of vascular endothelial growth factor and transforming growth factor\u2010beta1 as well as high ALK1 tissue expression","volume":"90","author":"Sadick 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