{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:21:55Z","timestamp":1762161715544,"version":"3.41.2"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T00:00:00Z","timestamp":1657238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Endoscopy has long been widely used to screen for esophageal varices (EV) in cirrhotic patients. Recurrent endoscopy is a significant burden for the healthcare system of the endoscopic unit as well as uncomfortable and high costs for patients. This study intended to prognosticate Right Liver Lobe Diameter\/Serum Albumin Ratio (RLLD\/Alb) as a non\u2010invasive approach in the early diagnosis of EV among chronic liver disease (CLD) Bangladeshi patients enrolled in a specific hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants and Methods<\/jats:title><jats:p>A total of 150 admitted patients with CLD were included in the study. Patients were subjected through a comprehensive biochemical checkup and upper digestive endoscopic or ultrasonographic inspection. The correlation was evaluated between the RLLD\/Alb ratio and esophageal varices grades.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The upper digestive endoscopy demonstration among 150 patients resulted in no EV in 18%, while 24% of patients was identified as EV grade I, 20% as grade II, 20% as grade III, and 18% patients as grade IV. The mean value of the RLLD\/Alb ratio was 4.89\u2009\u00b1\u20091.49 (range from 2.30 to 8.45). The RLLD\/Alb ratio diagnosed the EV employing the cut\u2010off value of 4.01 with 85.3% sensitivity and 68.8% specificity. Furthermore, it was positively correlated with the grading of EV, when this ratio increased the grading of EV increases and vice versa (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.630, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The RLLD\/Alb ratio is a non\u2010invasive parameter giving exact guidance relevant to the ascertainment of the existence of EV and their grading in chronic liver disease patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24589","type":"journal-article","created":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T06:35:27Z","timestamp":1657348527000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>RLLB<\/scp>\/Alb ratio:\u00a0a promising noninvasive diagnostic marker in assessing esophageal varices in cirrhotic patients"],"prefix":"10.1002","volume":"36","author":[{"given":"Md Faisal Fahad","family":"Chowdhury","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Chittagong Medical College Hospital  Chattogram Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3395-0320","authenticated-orcid":false,"given":"Ashekul","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Mawlana Bhashani Science and Technology University  Tangail Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pulak Kanti","family":"Palit","sequence":"additional","affiliation":[{"name":"Department of Medicine Chittagong Medical College  Chattogram Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md.","family":"Mozibullah","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Mawlana Bhashani Science and Technology University  Tangail Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md","family":"Sohel","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Mawlana Bhashani Science and Technology University  Tangail Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mst Mahmuda","family":"Khatun","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Mawlana Bhashani Science and Technology University  Tangail Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Mehadi Hassan","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Microbiology Noakhali Science and Technology University  Noakhali Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammod Johirul","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Mawlana Bhashani Science and Technology University  Tangail Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyonti","family":"Datta","sequence":"additional","affiliation":[{"name":"Department of Medicine Chittagong Medical College  Chattogram Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suman","family":"Dhar","sequence":"additional","affiliation":[{"name":"Department of Medicine Chittagong Medical College  Chattogram Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradip Kumar","family":"Nath","sequence":"additional","affiliation":[{"name":"Department of Medicine Chittagong Medical College  Chattogram Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabuj Kanti","family":"Nath","sequence":"additional","affiliation":[{"name":"Department of Medicine Chittagong Medical College  Chattogram 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