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Herein, we systematically searched for neuropathic pain\u2010related ncRNAs expression changes, including microRNAs (miRNAs), long non\u2010coding RNAs (lncRNAs), and circular non\u2010coding RNAs (circRNAs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched two databases, PubMed and GeenMedical, for relevant studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Peripheral nerve injury or noxious stimuli can induce extensive changes in the expression of ncRNAs. For example, higher serum miR\u2010132\u20103p, \u2010146b\u20105p, and \u2010384 was observed in neuropathic pain patients. Either sciatic nerve ligation, dorsal root ganglion (DRG) transaction, or ventral root transection (VRT) could upregulate miR\u201021 and miR\u201031 while downregulating miR\u2010668 and miR\u2010672 in the injured DRG. lncRNAs, such as early growth response 2\u2010antisense\u2010RNA (Egr2\u2010AS\u2010RNA) and Kcna2\u2010AS\u2010RNA, were upregulated in Schwann cells and inflicted DRG after nerve injury, respectively. Dysregulated circRNA homeodomain\u2010interacting protein kinase 3 (circHIPK3) in serum and the DRG, abnormally expressed lncRNAs X\u2010inactive specific transcript (XIST), nuclear enriched abundant transcript 1 (NEAT1), small nucleolar RNA host gene 1 (SNHG1), as well as ciRS\u20107, zinc finger protein 609 (cirZNF609), circ_0005075, and circAnks1a in the spinal cord were suggested to participate in neuropathic pain development. Dysregulated miRNAs contribute to neuropathic pain via neuroinflammation, autophagy, abnormal ion channel expression, regulating pain\u2010related mediators, protein kinases, structural proteins, neurotransmission excitatory\u2013inhibitory imbalances, or exosome miRNA\u2010mediated neuron\u2013glia communication. In addition, lncRNAs and circRNAs are essential in neuropathic pain by acting as antisense RNA and miRNA sponges, epigenetically regulating pain\u2010related molecules expression, or modulating miRNA processing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Numerous dysregulated ncRNAs have been suggested to participate in neuropathic pain development. However, there is much work to be done before ncRNA\u2010based analgesics can be clinically used for various reasons such as conservation among species, proper delivery, stability, and off\u2010target effects.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24592","type":"journal-article","created":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T07:19:35Z","timestamp":1657351175000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["The etiological roles of <scp>miRNAs<\/scp>, <scp>lncRNAs<\/scp>, and <scp>circRNAs<\/scp> in neuropathic pain: A narrative review"],"prefix":"10.1002","volume":"36","author":[{"given":"Ming","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Nanjing Maternity and Child Health Care Hospital Women's Hospital of Nanjing Medical University  Nanjing 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