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Clinical characteristics and laboratory indexes between the high ferritin SSc group and the normal ferritin SSc group were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The level of SF in SSc patients was significantly higher than that in HCs (319.78 [179, 554.33] ng\/ml vs. 99 [49.03, 164.29] ng\/ml, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Compared with the normal ferritin SSc group, the high ferritin SSc group was more likely to develop skin diffuse cutaneous SSc, fingertip arthralgia, and cardiac involvement. In addition, the levels of glutamine transaminase (GGT), alanine aminotransferase (ALT), creatine kinase (CK), creatine kinase isoenzyme\u2010MB (CK\u2010MB), lactate dehydrogenase (LD), immunoglobulin G (IgG), immunoglobulin A (IgA), C\u2010reactive protein (CRP), erythrocyte sedimentation rate (ESR), and the positive rate of anti\u2010Scl70 antibody in the high ferritin SSc group were significantly higher (each <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). SF was positively correlated with GGT, ALT, CK, CK\u2010MB, LD, IgA, CRP, and ESR (each <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Multiple linear regression analysis showed that cardiac involvement, ALT, and ESR were independent influencing factors of SF in SSc.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study shows that the level of SF in patients with SSc is increased, and the elevated SF is related to abnormal liver function, myocardial involvement, inflammatory status, and production of autoantibodies in SSc. Cardiac involvement, ALT, and ESR are independent factors affecting SF in SSc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24597","type":"journal-article","created":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T07:23:30Z","timestamp":1657351410000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical significance of serum ferritin in patients with systemic sclerosis"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6578-4788","authenticated-orcid":false,"given":"Yanting","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory First Affiliated Hospital of Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1981-9273","authenticated-orcid":false,"given":"Xi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical 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