{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:17:02Z","timestamp":1782209822546,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We performed a cross\u2010sectional study to investigate the clinical usefulness of YKL\u201040 in patients with dermatomyositis (DM) and conducted a systematic review to summarize the clinical value of YKL\u201040 in patients with polymyositis (PM)\/DM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A cross\u2010sectional study and a systematic review were performed to study the clinical value of YKL\u201040 in patients with PM\/DM. Serum YKL\u201040 level was detected using enzyme\u2010linked immunosorbent assay, and its association with clinical and laboratory parameters was analyzed. In the systematic review, electronic databases of OVID Embase, OVID Medline, and web of science were searched to collect studies that reported clinical use of YKL\u201040 in patients with PM\/DM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the cross\u2010sectional study, serum YKL\u201040 level was higher in patients with DM than in healthy controls (median [interquartile range]: 84.09 [52.72\u2013176.4] ng\/ml versus 27.37 [12.30\u201353.58] ng\/ml, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Serum levels of YKL\u201040 were associated with the course of DM (r\u00a0=\u00a0\u22120.469, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), CRP (r\u00a0=\u00a00.303, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.043), CK (r\u00a0=\u00a00.263, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.037), and global disease activity (r\u00a0=\u00a00.628, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The area under the ROC curve was 0.835 (95% confidence interval 0.751\u20130.920). In the systematic review, a total of four studies were included with moderate to high quality. Serum level of YKL\u201040 has the possibility for diagnosing PM\/DM, identifying PM\/DM patients with interstitial lung disease (ILD) or rapid progress ILD, and predicting death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum YKL\u201040 level is a possible useful biomarker for PM\/DM diagnosis and may be used to predict prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24605","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T09:03:35Z","timestamp":1657875815000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinical value of <scp>YKL<\/scp>\u201040 in patients with polymyositis\/dermatomyositis: A cross\u2010sectional study and a systematic review"],"prefix":"10.1002","volume":"36","author":[{"given":"Beibei","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengming","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yupeng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunru","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geng","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of General Practice General Practice Medical Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6727-1839","authenticated-orcid":false,"given":"Qibing","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14368-1"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3704"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12451"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.06.1309"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9141420"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2018.03.042"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000329"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40320"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-019-04512-6"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42358-021-00199-z"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004563218786979"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-019-04457-w"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.170373"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000011775"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23963"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jebm.12141"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.15716"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2020.09.035"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.119.006643"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2020.1750811"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009727"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.24605","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcla.24605","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.24605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T03:10:07Z","timestamp":1692673807000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.24605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,15]]},"references-count":22,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1002\/jcla.24605"],"URL":"https:\/\/doi.org\/10.1002\/jcla.24605","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,15]]},"assertion":[{"value":"2022-03-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e24605"}}