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All samples were genotyped for patatin\u2010like phospholipase domain containing 3 (<jats:italic>PNPLA3<\/jats:italic>) rs738409, transmembrane 6 superfamily member 2 (<jats:italic>TM6SF2<\/jats:italic>) rs58542926, membrane\u2010bound O\u2010acyltransferase domain containing 7 (<jats:italic>MBOAT7<\/jats:italic>) rs641738, glucokinase regulator (<jats:italic>GCKR<\/jats:italic>) rs1260326 and rs780094, and GATA zinc finger domain containing 2A (<jats:italic>GATAD2A<\/jats:italic>) rs4808199. Using logistic regression analysis, we evaluated the association between MAFLD and each SNP under different models. Multiple linear regression was used to find the association between SNPs and laboratory characteristics. Multifactor dimensionality reduction was applied to test SNP\u2013SNP interactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The recessive model and additive model of <jats:italic>PNPLA3<\/jats:italic> rs738409 variant were related to MAFLD (odds ratio [OR]\u00a0=\u00a01.791 and 1.377, respectively, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.038 and 0.027, respectively). However, after Benjamini\u2010Hochberg adjustment for multiple tests, all associations were no longer statistically significant. <jats:italic>PNPLA3<\/jats:italic> rs738409 correlated with AST levels. <jats:italic>GCKR<\/jats:italic> rs780094 and rs1260326 negatively correlated with serum glucose but positively correlated with triglycerides in MAFLD. Based on MDR analysis, the best single\u2010locus and multilocus models for MAFLD risk were rs738409 and six\u2010locus models, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the Han population in western China, no association was found between these SNPs and the risk of MAFLD. <jats:italic>PNPLA3<\/jats:italic> rs738409 was associated with aspartate aminotransferase levels in MAFLD patients. <jats:italic>GCKR<\/jats:italic> variants were associated with increased triglyceride levels and reduced serum fasting glucose in patients with MAFLD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24626","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T20:44:55Z","timestamp":1658868295000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Genetic variants associated with metabolic dysfunction\u2010associated fatty liver disease in western 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