{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T10:25:52Z","timestamp":1770891952211,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:00:00Z","timestamp":1659398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gestational diabetes mellitus (GDM) and gestational diabetic nephropathy (GDN) have become an increasingly serious problem worldwide, which can cause a large number of adverse pregnancy consequences for mothers and infants. However, the diagnosis of GDM and GDN remains a challenge due to the lack of optimal biomarkers, and the examination has high requirements for patient compliance. We aimed to establish a simple early diagnostic model for GDM and GDN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 50 healthy pregnant (HP), 99 GDM patients, 99 GDN patients at Daping Hospital. Renal function indicators and blood cell indicators were collected for all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with HP, GDM, and GDN patients exhibited significantly higher urea\/creatinine ratio and NEU. The diagnostic model1 based on the combination of urea\/creatinine ratio and NEU was built using logistic regression. Based on receiver operating characteristic curve analysis, the area under the curve (AUC) of the diagnostic model was 0.77 (0.7, 0.84) in distinguishing GDM from HP, and the AUC of the diagnostic model was 0.94 (0.9, 0.97) in distinguishing GDN from HP. Meanwhile, the diagnostic model2 based on the combination of \u03b22\u2010mG, PLT, and NEU in GDM and GDN patients was built using logistic regression, and the area under the ROC curve (AUC ROC) was 0.79 (0.73, 0.85), which was larger than the individual biomarker AUC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study demonstrated that the diagnostic model established by the combination of renal function indicators and blood cell indicators could facilitate the differential diagnosis of GDM and GDN patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24627","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T20:06:01Z","timestamp":1659470761000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The diagnostic model for early detection of gestational diabetes mellitus and gestational diabetic nephropathy"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8335-7352","authenticated-orcid":false,"given":"Huimin","family":"Chong","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Daping Hospital Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinmi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Daping Hospital Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caigui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory and Pathology The People's Liberation Army 77th Group Army Hospital  Leshan Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Daping Hospital Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6515-8621","authenticated-orcid":false,"given":"Dan","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Daping Hospital Third Military Medical University (Army Medical University)  Chongqing China"},{"name":"Department of Clinical Laboratory Chongqing Health Center for Women and Children  Chongqing China"},{"name":"Department of Clinical Laboratory Women and Children's Hospital of Chongqing Medical University  Chongqing 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