{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:07:16Z","timestamp":1783426036439,"version":"3.54.6"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81560398, 82060448"],"award-info":[{"award-number":["81560398, 82060448"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004637","name":"Nanchang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004637","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Given that the onset of diseases including colorectal cancer precursors is affecting younger individuals and that obesity is an important risk factor for early\u2010onset, we conducted a study to explore the biochemical profile of differences in serum between early\u2010onset patients and late\u2010onset colorectal precancerous lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1447 patients, including 469 early\u2010onset patients and 978 late\u2010onset patients, were enrolled from the First Affiliated Hospital of Nanchang University (FAHNU), of which there were 311 sessile serrated adenoma\/polyps (SSA\/P) and 1136 normal adenomas. The distribution of the included categorical variables was compared via Pearson's chi\u2010squared test, whereas continuous variables were compared by using the nonparametric Kruskal\u2013Wallis test and <jats:sc>ANOVA<\/jats:sc>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with late\u2010onset patients, the levels of total bilirubin and HDL\u2010C were lower (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), whereas triglyceride and uric acid levels were higher, in early\u2010onset patients. Interestingly, in the subgroup analysis, triglyceride and uric acid levels remained at higher levels, whereas HDL\u2010C remained at lower levels, in early\u2010onset patients than in late\u2010onset patients. Other characteristics, such as LDL\u2010C, drinking, \u03b3\u2010GT, and the N\/L ratio, were similar between the two groups. An additional analysis of the association of tumor size with markers showed that lower levels of HDL\u2010C and higher levels of uric acid were associated with increased tumor size (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early\u2010onset CRC precursor cases exhibit higher levels of triglycerides and lower levels of HDL\u2010C than late\u2010onset cases. Additionally, levels of HDL\u2010C are negatively associated with tumor size, whereas uric acid was positively correlated with tumor size.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24637","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T07:37:52Z","timestamp":1660635472000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of some biochemical markers between early\u2010onset and late\u2010onset colorectal precancerous lesions: A single\u2010center retrospective study"],"prefix":"10.1002","volume":"36","author":[{"given":"Chao\u2010Tao","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Digestive Disease Hospital The First Affiliated Hospital of Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of 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