{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:16:06Z","timestamp":1787501766975,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Proinflammatory cytokines mediate anxiety and depression in various ways, such as immunity, inflammation, and the hypothalamic\u2013pituitary\u2013adrenal axis. This study intended to further explore the linkage of common proinflammatory cytokine levels with anxiety and depression in psoriasis patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Totally, 150 psoriasis patients and 50 healthy controls (HCs) were included; the serum samples were collected, then common proinflammatory cytokines were measured by ELISA. Hospital Anxiety and Depression Scale (HADS) was assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HADS\u2010anxiety (HADS\u2010A) score, HADS\u2010depression (HADS\u2010D) score, TNF\u2010\u03b1, IL\u20101\u03b2, IL\u20106, IL\u201012, IL\u201017A, and IL\u201023 were all increased in psoriasis patients compared to HCs (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). In psoriasis patients, TNF\u2010\u03b1 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001), IL\u201012 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.035), and IL\u201017A (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), but not IL\u20101\u03b2 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.255), IL\u20106 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.248), and IL\u201023 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.216), were positively linked to HADS\u2010A score. Meanwhile, TNF\u2010\u03b1 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.007) and IL\u201017A (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.007) were enhanced in psoriasis patients with anxiety in contrast to those without anxiety; whereas IL\u20101\u03b2 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.178), IL\u20106 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.360), IL\u201012 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.239), and IL\u201023 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.450) were not different. TNF\u2010\u03b1 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), IL\u20101\u03b2 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.013), Il\u201017A (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and IL\u201023 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.023), but not IL\u20106 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.143) and IL\u201012 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.158), were positively linked to HADS\u2010D score. Concurrently, TNF\u2010\u03b1 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.015), IL\u201017A (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and IL\u201023 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.017) were climbed in psoriasis patients with depression by comparison to those without depression; whereas IL\u20101\u03b2 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.113), IL\u20106 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.237), IL\u201012 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.660) did not differ.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TNF\u2010\u03b1, IL\u201017A, and IL\u201023 increments reflect anabatic anxiety and depression in psoriasis patients, uncovering the potency of proinflammatory cytokines measurement for monitoring or even preventing psoriasis patients' anxiety and depression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.24643","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T15:14:13Z","timestamp":1660058053000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The potency of common proinflammatory cytokines measurement for revealing the risk and severity of anxiety and depression in psoriasis patients"],"prefix":"10.1002","volume":"36","author":[{"given":"Nannan","family":"Tong","sequence":"first","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Harbin Medical University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Harbin Medical University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anping","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Harbin Medical University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Harbin Medical University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8646-0275","authenticated-orcid":false,"given":"Siyu","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Harbin Medical University Harbin China"},{"name":"Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education The Second Affiliated Hospital of Harbin Medical University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32549-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1590"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-020-01346-6"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00293-y"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.711060"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1203475420952420"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-020-02621-3"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.12740\/PP\/68948"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.771645"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtumed.2021.02.008"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2020.110347"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.09.001"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115903"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004411"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13529"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"issue":"4","key":"e_1_2_9_18_1","first-page":"480","article-title":"Anxiety and depression as comorbidities of multiple sclerosis","volume":"33","author":"Mustac F","year":"2021","journal-title":"Psychiatr Danub"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2021.102776"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0241445"},{"issue":"1","key":"e_1_2_9_21_1","doi-asserted-by":"crossref","first-page":"S195","DOI":"10.4103\/0972-6748.328861","article-title":"Assessment of depression, anxiety, stress, and quality of life in rheumatoid arthritis patients and comparison with healthy individuals","volume":"30","author":"Khan A","year":"2021","journal-title":"Ind Psychiatry J"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-81213-8"},{"issue":"4","key":"e_1_2_9_23_1","first-page":"553","article-title":"Study on the impact of psoriasis on quality of life: psychological, social and financial implications","volume":"32","author":"Bulat V","year":"2020","journal-title":"Psychiatr Danub"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocn.15577"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4006"},{"issue":"7","key":"e_1_2_9_26_1","first-page":"675","article-title":"Cytokines of the IL\u201017 family in psoriasis","volume":"18","author":"Lauffer F","year":"2020","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22158076"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-018-0505-z"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2021.105200"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.102982"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-020-05326-7"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14720"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21062194"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.24643","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcla.24643","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.24643","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T22:10:13Z","timestamp":1727734213000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.24643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,9]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1002\/jcla.24643"],"URL":"https:\/\/doi.org\/10.1002\/jcla.24643","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,9]]},"assertion":[{"value":"2022-07-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e24643"}}