{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:27:35Z","timestamp":1782941255563,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81902117"],"award-info":[{"award-number":["81902117"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It is critical for laboratories to conduct multianalyzer comparisons as a part of daily routine work to strengthen the quality management of test systems. Here, we explored the application of patient\u2010based real\u2010time quality controls (PBRTQCs) on comparative assays to monitor the consistency among clinical laboratories.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present study included 11 commonly tested analytes that were detected using three analyzers. PBRTQC procedures were set up with exponentially weighted moving average (EWMA) algorithms and evaluated using the AI\u2010MA artificial intelligence platform. Comparative assays were carried out on serum samples, and patient data were collected. Patients were divided into total patient (TP), inpatient (IP), and outpatient (OP) groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Optimal PBRTQC protocols were evaluated and selected with appropriate truncation limits and smoothing factors. Generally, similar comparative assay performance was achieved using both the EWMA and median methods. Good consistency between the results from patients' data and serum samples was obtained, and unacceptable bias was detected for alkaline phosphatase (ALP) and gamma\u2010glutamyl transferase (GGT) when using analyzer C. Categorizing patients' data and applying specific groups for comparative assays could significantly improve the performance of PBRTQCs. When monitoring the inter\u2010 and intraanalyzer stability on a daily basis, EWMA was superior in detecting very small quality\u2010related changes with lower false\u2010positive alarms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found that PBRTQCs have the potential to efficiently assess multianalyzer comparability. Laboratories should be aware of population variations concerning both analytes and analyzers to build more suitable PBRTQC protocols.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24651","type":"journal-article","created":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T03:59:45Z","timestamp":1660190385000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Assessment of patient based real\u2010time quality control on comparative assays for common clinical analytes"],"prefix":"10.1002","volume":"36","author":[{"given":"Yide","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Ruijin Hospital, Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Ruijin Hospital, Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Wen","sequence":"additional","affiliation":[{"name":"Shanghai Senxu Medical Technology Corporation  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaifeng","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Ruijin Hospital, Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichao","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Ruijin Hospital, Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuya","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Ruijin Hospital, Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Ruijin Hospital, Shanghai Jiaotong University School of Medicine  Shanghai China"},{"name":"Faculty of Medical Laboratory Science Ruijin Hospital, Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1023-202X","authenticated-orcid":false,"given":"Danfeng","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Ruijin Hospital, Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2013.220376"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2010.148106"},{"key":"e_1_2_10_4_1","first-page":"204","article-title":"A new quality control method based on a moving average of \"latent reference values\" selected from patients' daily test results","volume":"52","author":"Hayashi S","year":"2004","journal-title":"Rinsho Byori"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-9140(84)80214-3"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2014.12.016"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2019-1024"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/61.4.473"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/81.4.492"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/105.1.44"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2015.03.003"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2016-0270"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408363.2020.1765731"},{"key":"e_1_2_10_14_1","unstructured":"AarsandAK F\u2010CP WebsterC CoskunA Gonzales\u2010LaoE Diaz\u2010GarzonJ JonkerN MinchinelaJ SimonM BragaF PerichC BonedB RoraasT Marques\u2010GarciaF CarobeneA AslanB BarlettWA SandbergS.The EFLM Biological Variation Databasehttps:\/\/biologicalvariation.eu\/"},{"key":"e_1_2_10_15_1","unstructured":"W. ChenHS Z.Shen Z.Wang C.Zhang X.Li F.He X.Wang L.Qiu X.Liu.WS\/T 403\u20132012 Analytical Quality Specifications for Routine Analytes in Clinical Biochemistry.2012."},{"key":"e_1_2_10_16_1","volume-title":"Measurement Procedure Comparison and Bias Estimation Using Patient Samples","author":"Institute CaLS","year":"2013"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2019-0732"},{"key":"e_1_2_10_18_1","unstructured":"Assessment CNASfC.Guidance on the application of accreditation criteria for the medical laboratory quality and competence in the field of Clinical Chemistry2018."},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/hvaa094"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2016.257055"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2020.10.006"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2018-0795"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23314"},{"key":"e_1_2_10_24_1","first-page":"1549","article-title":"Douwe van loon, Herman Steigstra, Christa Cobbaert, general chemistry division of the SKML (Foundation for Quality Assessment in medical laboratories, The Netherlands). Harmonisation of seven common enzyme results through EQA","volume":"52","author":"Cas Weykamp PF","year":"2014","journal-title":"Clin Chem Lab Med"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.11613\/BM.2021.020705"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.24651","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcla.24651","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.24651","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T03:08:09Z","timestamp":1692673689000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.24651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,10]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1002\/jcla.24651"],"URL":"https:\/\/doi.org\/10.1002\/jcla.24651","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,10]]},"assertion":[{"value":"2022-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e24651"}}