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However, BTMs in children are challenging, and few studies explore these BTMs in children. The application of BTMs is complicated mainly due to pre\u2010analytical factors, variable reference intervals of age\u2010 and sex\u2010related BTMs for adolescents and children in different regions and laboratories. Therefore, laboratory testing of BTMs is critical for understanding pediatric bone development and metabolism, which provides additional information about bone development and diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Literature search was conducted using the MeSH term \u201cchild\u201d combined with the terms that bone turnover markers such as \u201costeocalcin,\u201d \u201cProcollagen type I N\u2010terminal propeptide,\u201d \u201cprocollagen type I C\u2010terminal propeptide,\u201d \u201costeocalcin,\u201d \u201cN\u2010terminal cross\u2010linked telopeptide,\u201d and \u201cC\u2010terminal cross\u2010linked telopeptide,\u201d Several databases including Web of Science, Google Scholar, and PubMed were searched to obtain the relevant studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>BTMs represent the combined effects of skeletal development, growth, and remodeling in children, which can be used in clinical pediatrics to assist in the diagnosis and prognosis of bone metabolic disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>BTMs are clearly helpful for diagnosis and monitoring of bone growth and development as well as bone metabolic disorders.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24656","type":"journal-article","created":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T03:47:53Z","timestamp":1660189673000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Broad application prospects of bone turnover markers in pediatrics"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9414-574X","authenticated-orcid":false,"given":"Yiduo","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine West China Second University Hospital, Sichuan University  Chengdu China"},{"name":"Key Laboratory of Birth Defects and 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