{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T16:00:47Z","timestamp":1772726447259,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T00:00:00Z","timestamp":1661040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>At present, there is a new variant Omicron BA.2 of SARS\u2010CoV\u20102. In some previous studies, it was found that CBC, NLR, CRP, SAA, etc. in patients with SARS\u2010CoV\u20102 had a series of changes, which were significantly correlated with the diagnosis and prognosis of patients. Therefore, in order to find specific diagnostic indicators, we explore the changes in these blood indicators and inflammatory indicators in patients with the SARS\u2010CoV\u20102 Omicron.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 127 Omicron confirmed patients who had visited fever clinic was selected as the positive group, and 75 Omicron excluded patients were selected as the negative group. We collected and analyzed the CBC, CRP, SAA test data, and clinical data of all subjects for analysis and statistics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      WBC, NEU, LYM, EOS, PLT, PCT, LYM * NEU count compared with the negative group were significantly lower (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05); on the contrary, CNR were significantly higher (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05); The levels of CRP and SAA were not significantly different from those of the negative group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05); the AUC of 0.781 for the diagnosis of LYM * NEU with an optimal cutoff value of 5.79, with a sensitivity and specificity of 68% and 73%, respectively, Youden index of 0.41, giving the best diagnostic performance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The decreased LYM * NEU count can be used as the early, rapid, and accurate diagnostic indicator for Omicron. While due to the attenuated toxicity of BA.2 sublineage, CRP and SAA had no significance in the differential diagnosis of confirmed patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.24671","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T02:04:28Z","timestamp":1661133868000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["\u201cLymphocyte * Neutrophil\u201d count decreased in\n                    <scp>SARS\u2010CoV<\/scp>\n                    \u20102 Omicron patients in Shanghai with no significant change in\n                    <scp>CRP<\/scp>\n                    and\n                    <scp>SAA<\/scp>"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1168-2962","authenticated-orcid":false,"given":"Huanhuan","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine,Shanghai TCM\u2010Integrated Hospital Shanghai University of Traditional Chinese Meadicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9446-5076","authenticated-orcid":false,"given":"Jiao","family":"Li","sequence":"additional","affiliation":[{"name":"Teaching Laboratory Center of Medicine, School of Medicine Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00838-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.5114\/fmpcr.2020.95311"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.67.suppl1.20200678"},{"issue":"4","key":"e_1_2_9_5_1","first-page":"847","article-title":"Neutrophil to lymphocyte ratio is a useful predictor of atrial fibrillation in patients with diabetes mellitus[J]","volume":"29","author":"Sahin S","year":"2013","journal-title":"Acta Medica Mediterranea"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.63.12.1065"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcd.2021.08.015"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.20220236"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/prm2.12065"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000002296"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.052"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00618.2015"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.00658"},{"key":"e_1_2_9_14_1","unstructured":"Tracking SARS\u2010CoV\u20102 Variants;(Cited 2021 November) Available from:https:\/\/www.who.int\/en\/activities\/tracking\u2010SARS\u2010CoV\u20102\u2010variants\/"},{"key":"e_1_2_9_15_1","article-title":"Omicron: a heavily mutated SARS\u2010CoV\u20102 variant exhibits stronger binding to ACE2 and potently escape approved COVID\u201019 therapeutic antibodies","volume":"12","author":"Woo HG","year":"2021","journal-title":"Front Immunol"},{"key":"e_1_2_9_16_1","unstructured":"HKUMed finds Omicron SARS\u2010CoV\u20102 can infect faster and better than Delta in hu\u2010man bronchus but with less severe infection in Lung;(Cited Dec 2021).Available from:https:\/\/www.med.hku.hk\/en\/news\/press\/20211215\u2010omicron\u2010SARS\u2010CoV\u20102\u2010infection"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04479-6"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7115e1"},{"key":"e_1_2_9_19_1","unstructured":"SARS\u2010CoV\u20102 Vaccination Status;(Cited Jun 1 2021). Available from:http:\/\/www.nhc.gov.cn\/epidemicprevention and control trends."},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2022.01.036"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-00880-9"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102763"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2020-0270"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22868-8"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2020.06.012"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjpo-2020-001011"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2021.1950898"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.5493\/wjem.v12.i2.26"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867323666160418114600"},{"issue":"32","key":"e_1_2_9_30_1","first-page":"9155","article-title":"Presence of a SARS\u2010CoV\u20102 protein enhances amyloid formation of serum amyloid A","volume":"125","author":"Jana AK","year":"2021","journal-title":"Cold Spring Harb Lab"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23527"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.24671","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcla.24671","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.24671","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T18:41:18Z","timestamp":1765305678000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.24671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,21]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1002\/jcla.24671"],"URL":"https:\/\/doi.org\/10.1002\/jcla.24671","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,21]]},"assertion":[{"value":"2022-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e24671"}}