{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:19:12Z","timestamp":1791908352193,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Interleukin (IL)\u201041, also known as Metrnl, is a novel immunomodulatory cytokine, which is involved in the pathogenesis of many inflammatory and metabolic diseases, but its role in thyroid autoimmune diseases is not clear. The aim of this study was to evaluate the serum IL\u201041 levels in patients with Graves' disease (GD) and its relationship with GD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included a total of 49 GD patients and 47 age\u2010 and sex\u2010matched healthy individuals. All baseline data were obtained by physical examination. Free triiodothyronine 3 (FT3), free triiodothyronine 4 (FT4), thyroid\u2010stimulating hormone (TSH), anti\u2010thyroglobulin antibodies (TgAb), thyroid peroxidase antibody (TPOAb), and thyrotropin receptor antibody (TRAb) levels in plasma of GD patients were measured by chemiluminescence. The high\u2010sensitivity C\u2010reactive protein (CRP) and white blood cell count (WBC) were detected using automated biochemical analyzer. Serum IL\u201041 levels were measured by enzyme\u2010linked immunosorbent assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Serum IL\u201041 levels in patients with GD were significantly lower than those in healthy controls (201.0 vs. 260.8\u2009pg\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). There was a significant positive correlation between IL\u201041 level and CRP (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.2947,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0385) and WBC (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.4104,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0034) in GD patients. CRP was positively correlated with TRAb (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.2874,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0452) and TSH (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.3651,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0099) levels in GD patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrates that GD patients have decreased serum IL\u201041 levels, and IL\u201041 plays a potential role in abnormal immune response of GD patients.<\/jats:p>\n                  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Pathophysiology Ningbo University School of Medicine  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3910-6964","authenticated-orcid":false,"given":"Mingcai","family":"Li","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Medical School Ningbo University  Ningbo China"},{"name":"Zhejiang Key Laboratory of Pathophysiology Ningbo University School of Medicine  Ningbo 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