{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:52:15Z","timestamp":1787496735666,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,9,4]],"date-time":"2022-09-04T00:00:00Z","timestamp":1662249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diffuse large B\u2010cell lymphoma (DLBCL) is a highly aggressive form of non\u2010Hodgkin lymphoma. Long noncoding RNA (lncRNA) has been evaluated as prognostic markers in various carcinomas. However, the prognostic value of the lncRNA index in DLBCL has not been fully understood. Hence, this study aimed to identify the prognostic value of lncRNA olfactory receptor family 2 subfamily A member 1\u2010antisense RNA 1 (OR2A1\u2010AS1) in DLBCL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Gene Expression Omnibus (GEO) database was used to obtain the GSE97336 dataset comprising lncRNA expression profiles. Quantitative reverse transcription polymerase chain reaction (QRT\u2010PCR) was conducted to evaluate the expression of OR2A1\u2010AS1 in 98 cases of DLBCL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>OR2A1\u2010AS1 expression was considerably reduced in DLBCL patients, reduced OR2A1\u2010AS1 expression was linked to a shorter overall survival (OS) and progression\u2010free survival (PFS) in DLBCL patients, especially those with the germinal center B\u2010cell\u2010like subtype (GCB). Multivariate analysis (MVA) revealed that the OR2A1\u2010AS1 index had prognostic significance. Patients with low OR2A1\u2010AS1 expression have a poor prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>OR2A1\u2010AS may represent an effective predictor of patients' outcomes with DLBCL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.24680","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:34:15Z","timestamp":1662338055000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<scp>LncRNA OR2A1\u2010AS1<\/scp>\n                    index predicts survival in germinal center\u2010like diffuse large B\u2010cell lymphoma"],"prefix":"10.1002","volume":"36","author":[{"given":"Shuting","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Hematology The First People's Hospital of Wenling  Wenling China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Hematology The First People's Hospital of Wenling  Wenling China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pathology The First People's Hospital of Wenling  Wenling China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengjun","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine The First People's Hospital of Wenling  Wenling China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3486-278X","authenticated-orcid":false,"given":"Meiyun","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Hematology The First People's Hospital of Wenling  Wenling 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