{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T02:18:56Z","timestamp":1789006736332,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vascular cell adhesion molecule\u20101 (VCAM\u20101) and intercellular adhesion molecule\u20101 (ICAM\u20101) modulate atherosclerosis by promoting leukocyte infiltration, neutrophil recruitment, endothelial cell proliferation, etc., which may directly or indirectly facilitate the occurrence of major adverse cardiac events (MACE). This study intended to investigate the value of VCAM\u20101 and ICAM\u20101 for predicting MACE in ST\u2010segment elevation myocardial infarction (STEMI) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Totally, 373 STEMI patients receiving the percutaneous coronary intervention and 50 health controls (HCs) were included. Serum VCAM\u20101 and ICAM\u20101 were detected by ELISA. Meanwhile, MACE was recorded during a median follow\u2010up of 18 (range: 1\u201346)\u00a0months in STEMI patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Vascular cell adhesion molecule\u20101 and ICAM\u20101 were raised in STEMI patients compared with HCs (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). VCAM\u20101 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002) and ICAM\u20101 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.012) high were linked with raised accumulating MACE rate in STEMI patients. Notably, VCAM\u20101 high (hazard ratio [HR]\u00a0=\u00a02.339,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.031), age\u2009\u2265\u200965\u2009years (HR\u00a0=\u00a02.019,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.039), history of diabetes mellitus (DM) (HR\u00a0=\u00a02.395,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.011), C\u2010reactive protein (CRP)\u2009\u2265\u20095\u00a0mg\/L (HR\u00a0=\u00a02.550,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.012), multivessel disease (HR\u00a0=\u00a02.561,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.007) independently predicted MACE risk in STEMI patients. Furthermore, a nomogram\u2010based prediction model combining these factors was established, exhibiting an acceptable value for estimating 1, 2, and 3\u2010year MACE risk, with AUC of 0.764, 0.716, and 0.778, respectively, in STEMI patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study confirms the value of VCAM\u20101 and ICAM\u20101 measurement in predicting MACE risk in STEMI patients. Moreover, VCAM\u20101 plus other traditional prognostic factors (such as age, history of DM, CRP, and multivessel disease) cloud further improve the predictive accuracy of MACE risk in STEMI patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.24685","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T01:55:17Z","timestamp":1661997317000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Serum\n                    <scp>VCAM<\/scp>\n                    \u20101 and\n                    <scp>ICAM<\/scp>\n                    \u20101 measurement assists for\n                    <scp>MACE<\/scp>\n                    risk estimation in\n                    <scp>ST<\/scp>\n                    \u2010segment elevation myocardial infarction patients"],"prefix":"10.1002","volume":"36","author":[{"given":"Jiancai","family":"Yu","sequence":"first","affiliation":[{"name":"Tianjin Medical University  Tianjin China"},{"name":"Department of Cardiology Cangzhou Central Hospital of Tianjin Medical University  Cangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxing","family":"Liu","sequence":"additional","affiliation":[{"name":"Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanzhong","family":"Peng","sequence":"additional","affiliation":[{"name":"Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2336-9428","authenticated-orcid":false,"given":"Zesheng","family":"Xu","sequence":"additional","affiliation":[{"name":"Tianjin Medical University  Tianjin China"},{"name":"Department of Cardiology Cangzhou Central Hospital of Tianjin Medical University  Cangzhou 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