{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T03:15:09Z","timestamp":1778037309134,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:00:00Z","timestamp":1663027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vitreoretinal lymphoma (VRL) can commonly masquerade as chronic idiopathic uveitis due to its nonspecific clinical presentation. Thus, its early diagnosis is difficult. In this study, new logistic regression models were used to classify VRL and uveitis. Additionally, the diagnostic performance of interleukin (IL)\u201010, the IL\u201010\/IL\u20106, and the Interleukin Score for IntraOcular Lymphoma Diagnosis (ISOLD) are evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty\u2010nine aqueous humors (AH) (46 VRL, 23 uveitis) and 65 vitreous humors (VH) (49 VRL, 16 uveitis) were collected from a single\u2010center retrospective cohort. Logistic regression models were conducted based on IL\u20106 and IL\u201010. The cut\u2010off values, area under the receiver operating characteristic curve (ROC) curve (AUC), sensitivity and specificity of IL\u201010, the IL\u201010\/IL\u20106, the ISOLD, and the models were calculated from the ROC. Furthermore, Spearman's rank correlation analysis was performed to determine cytokine levels in VH and AH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We redefined the cut\u2010off values of IL\u201010, the IL\u201010\/IL\u20106, the ISOLD, and the logistic regression models. In AH, the AUC values of IL\u201010, ISOLD, IL10\/IL6, and the model were 0.91, 0.953, 0.952, and 0.967. In VH, they were 0.93, 0.95, 0.954, and 0.954, respectively. IL\u20106 (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.7844) and IL\u201010 (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.8506) in AH and VH showed a strong correlation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IL\u20106 and IL\u201010 levels were introduced into new logistic regression models. The diagnostic efficacy of the models improved compared to the indicators mentioned above among Chinese patients. Additionally, the models could predict the probability of VRL more accurately. A strong correlation of cytokine levels showed the great potential of AH as prioritized auxiliary diagnostic for VRL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.24689","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T04:47:34Z","timestamp":1663044454000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Logistic regression models of cytokines in differentiating vitreoretinal lymphoma from uveitis"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5336-7573","authenticated-orcid":false,"given":"Sha","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Huashan Hospital Fudan University  Shanghai China"},{"name":"Department of Ophthalmology, Jinshan Hospital Fudan University  Shanghai 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