{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T16:02:09Z","timestamp":1781625729429,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Long non\u2010coding RNA activated by DNA damage (lnc\u2010NORAD) modulates inflammation, lipid level, and atherosclerosis in various cardiovascular diseases. This study intended to investigate the dysregulated expression of lnc\u2010NORAD, and its linkage with clinical characteristics, inflammatory cytokines, and accumulating major adverse cardiovascular events (MACE) in coronary heart disease (CHD) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Totally, 160 CHD patients, 30 disease controls (DCs), and 30 healthy controls (HCs) were included. The reverse transcription\u2010quantitative polymerase chain reaction was used to detect lnc\u2010NORAD expression in peripheral blood mononuclear cell samples from all participants. Enzyme\u2010linked immunosorbent assay was applied to detect proinflammatory cytokines and adhesion molecules in CHD patients. Then, MACE was recorded during a median follow\u2010up of 12 (range: 1.0\u201327.0) months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lnc\u2010NORAD was highest in CHD patients, followed by DCs, and lowest in HCs (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In CHD patients, lnc\u2010NORAD was positively linked with Gensini score (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001). Meanwhile, lnc\u2010NORAD was positively linked to C\u2010reactive protein (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.023), tumor necrosis factor\u2010alpha (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.016), interleukin (IL)\u20106 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.003), IL\u20108 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.018), and IL\u201017A (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.029). No relation of lnc\u2010NORAD with vascular cell adhesion molecule\u20101 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.094) and intercellular adhesion molecule\u20101 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.060) was found. Furthermore, lnc\u2010NORAD was positively related to total cholesterol (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.014) and low\u2010density lipoprotein cholesterol (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.004), whereas lnc\u2010NORAD was not linked to triglyceride (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.103) and high\u2010density lipoprotein cholesterol (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.533). However, lnc\u2010NORAD (high vs. low), and its higher quartiles were both not linked to accumulating MACE rate (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Increased lnc\u2010NORAD is linked with aggravated stenosis degree, inflammation status, and blood lipid in CHD patients. However, further validation is required.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24717","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T02:59:50Z","timestamp":1667357990000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Increased long non\u2010coding <scp>RNA NORAD<\/scp> reflects serious cardiovascular stenosis, aggravated inflammation status, and higher lipid level in coronary heart disease"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2631-7706","authenticated-orcid":false,"given":"Xiaoyun","family":"Zhang","sequence":"first","affiliation":[{"name":"General Practice Tianjin Fifth Central Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuetong","family":"Kan","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Tianjin Fifth Central Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Tianjin Fifth Central Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Tianjin Fifth Central Hospital  Tianjin 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