{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:56:46Z","timestamp":1753869406823,"version":"3.41.2"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["No. H2021201024"],"award-info":[{"award-number":["No. H2021201024"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Inflammatory cytokines modulate atherogenesis and plaque rupture to involve in ST\u2010segment elevation myocardial infarction (STEMI) progression. The present study determined eight inflammatory cytokine levels in 212 percutaneous coronary intervention (PCI)\u2010treated STEMI patients, aiming to comprehensively investigate their potency in estimating major adverse cardiac event (MACE) risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum tumor necrosis factor (TNF)\u2010\u03b1, interleukin (IL)\u20101\u03b2, IL\u20106, IL\u20108, IL\u201010, IL\u201017A, vascular cell adhesion molecule\u20101 (VCAM\u20101), and intercellular adhesion molecule\u20101 (ICAM\u20101) of 212 PCI\u2010treated STEMI patients and 30 angina pectoris patients were determined using enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TNF\u2010\u03b1 (52.5 (43.9\u201362.6) pg\/ml versus 46.4 (39.0\u201359.1) pg\/ml, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.031), IL\u20108 (61.6 (49.6\u201381.7) pg\/ml versus 46.7 (32.5\u201363.1) pg\/ml, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001), IL\u201017A (57.4 (45.7\u201377.3) pg\/ml versus 43.2 (34.2\u201364.6) pg\/ml, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001), and VCAM\u20101 (593.6 (503.4\u2013811.4) ng\/ml versus 493.8 (390.3\u2013653.7) ng\/ml, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.004) levels were elevated in STEMI patients compared to angina pectoris patients, while IL\u20101\u03b2 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.069), IL\u20106 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.110), IL\u201010 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.052), and ICAM\u20101 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.069) were of no difference. Moreover, both IL\u201017A high (vs. low) (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.026) and VCAM\u20101 high (vs. low) (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.012) were linked with increased cumulative MACE rate. The multivariable Cox's analysis exhibited that IL\u201017A high (vs. low) (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.034) and VCAM\u20101 high (vs. low) (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.014) were independently associated with increased cumulative MACE risk. Additionally, age, diabetes mellitus, C\u2010reactive protein, multivessel disease, stent length, and stent type were also independent factors for cumulative MACE risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IL\u201017A and VCAM\u20101 high level independently correlate with elevated MACE risk in STEMI patients, implying its potency in identifying patients with poor prognoses.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24730","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T08:06:13Z","timestamp":1665993973000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The abnormal level and prognostic potency of multiple inflammatory cytokines in <scp>PCI<\/scp>\u2010treated <scp>STEMI<\/scp> patients"],"prefix":"10.1002","volume":"36","author":[{"given":"Jing","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiology 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