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We also outline the characteristics of PRA in different endocrine diseases and their clinical utility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant inconsistency was observed in PRA measurement methods, including immunoassay and isotope dilution liquid chromatography\u2013tandem mass spectrometry (ID\u2010LC\/MS\/MS), which could be attributed to preanalytical, analytical, and postanalytical variations. Meanwhile, consensus about environmental and procedural factors during the entire analytical process, including storage temperature, incubation condition, blank subtraction, and standardized operational procedures across different self\u2010developed assay laboratories, could be important to minimize analytical variations. Furthermore, commutable uniform calibrators should be prepared to improve consistency, ultimately achieving accurate and reliable measurement of PRA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This review summarizes the clinical utilization of PRA as a biomarker in multiple diseases, elaborating on routine detection methods and the key factors in the analytical process. We also provide feasible strategies for improving standardization and facilitating PRA assessment for larger\u2010scale clinical applications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24738","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T04:40:53Z","timestamp":1666759253000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The spectrum of plasma renin activity and hypertension diseases: Utility, outlook, and suggestions"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0825-6126","authenticated-orcid":false,"given":"Zhenni","family":"Liu","sequence":"first","affiliation":[{"name":"National Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital\/National Center of Gerontology, Beijing Engineering Research Center of Laboratory Medicine, Chinese Academy of Medical Sciences, 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