{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:32:11Z","timestamp":1790299931790,"version":"4.1.0"},"reference-count":251,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Klebsiella pneumoniae<\/jats:italic> is a notorious bacterium in clinical practice. Virulence, carbapenem\u2010resistance and their convergence among <jats:italic>K. pneumoniae<\/jats:italic> are extensively discussed in this article. Hypervirulent <jats:italic>K. pneumoniae<\/jats:italic> (HvKP) has spread from the Asian Pacific Rim to the world, inducing various invasive infections, such as pyogenic liver abscess, endophthalmitis, and meningitis. Furthermore, HvKP has acquired more and more drug resistance. Among multidrug\u2010resistant HvKP, hypervirulent carbapenem\u2010resistant <jats:italic>K. pneumoniae<\/jats:italic> (Hv\u2010CRKP), and carbapenem\u2010resistant hypervirulent <jats:italic>K. pneumoniae<\/jats:italic> (CR\u2010HvKP) are both devastating for their extreme drug resistance and virulence. The hypervirulence of HvKP is primarily attributed to hypercapsule, macromolecular exopolysaccharides, or excessive siderophores, although it has many other factors, for example, lipopolysaccharides, fimbriae, and porins. In contrast with classical determination of HvKP, that is, animal lethality test, molecular determination could be an optional and practical method after improvement. HvKP, including Hv\u2010CRKP and CR\u2010HvKP, has been progressing. R\u2010M and CRISPR\u2010Cas systems may play pivotal roles in such evolutions. Hv\u2010CRKP and CR\u2010HvKP, in particular the former, should be of severe concern due to their being more and more prevalent.<\/jats:p>","DOI":"10.1002\/jcla.24743","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T03:40:46Z","timestamp":1667965246000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":103,"title":["The making of hypervirulent <i>Klebsiella pneumoniae<\/i>"],"prefix":"10.1002","volume":"36","author":[{"given":"Piaopiao","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Taizhou Municipal Hospital  Taizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8042-9039","authenticated-orcid":false,"given":"Dakang","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Taizhou Municipal Hospital  Taizhou 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