{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:48:45Z","timestamp":1760986125443,"version":"3.41.2"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["No. 7222068"],"award-info":[{"award-number":["No. 7222068"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Arterial stiffness interacts with hypertension, becoming an early marker of hypertension\u2010mediated target organ damage. This study aimed to assess the association between plasma concentrations of bone morphogenetic protein\u20104 (BMP\u20104) and arterial stiffness during hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using cardio\u2010ankle vascular index (CAVI) to determine arterial stiffness status, 204 individuals with essential hypertension were classified into two groups, high CAVI (abnormal) group (<jats:italic>n<\/jats:italic>\u00a0=\u00a094) and low (normal) CAVI group (<jats:italic>n<\/jats:italic>\u00a0=\u00a0110). Data were collected including clinical characteristics and laboratory measurements. Plasma levels of BMP\u20104 were tested by using ELISA analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Plasma levels of BMP\u20104 were substantially greater in high CAVI group than that in low CAVI group [38.51 (31.79\u201350.83)\u00a0pg\/mL vs. 31.15 (29.38\u201332.37)\u00a0pg\/mL; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001]. As shown by spearman correlation analysis, BMP\u20104 concentrations were correlated with CAVI values in hypertensive individuals (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.406, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). After adjustment for potential confounders, elevated BMP\u20104 levels were related with high CAVI (OR, 1.070; 95% CI, 1.003\u20131.108; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The best BMP\u20104 cutoff value for identifying high CAVI, as determined by ROC curve analysis, was 33.34\u2009pg\/mL (AUC, 0.751; 95% CI, 0.683\u20130.818; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Plasma levels of BMP\u20104 are increased in hypertensive individuals with high CAVI. Elevated BMP\u20104 levels are strongly correlated with higher CAVI values, implying a predictive value of BMP\u20104 in arterial stiffness during hypertension.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24746","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T06:44:46Z","timestamp":1666939486000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association of plasma bone morphogenetic protein\u20104 levels with arterial stiffness in hypertensive patients"],"prefix":"10.1002","volume":"36","author":[{"given":"Ning","family":"Wang","sequence":"first","affiliation":[{"name":"Heart Center and Beijing Key Laboratory of Hypertension Beijing Chaoyang Hospital, Capital Medical University  Beijing China"},{"name":"Department of Geriatrics Beijing Tongren Hospital, Capital Medical University  Beijing 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