{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:32:06Z","timestamp":1771475526046,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Antiphospholipid (aPL) antibodies have been reported in several autoimmune diseases. The aim of this study was to evaluate the frequency of aPL (anti\u2010cardiolipin antibodies (aCL) and anti\u2010\u03b22 glycoprotein I antibodies (a\u03b22GPI)) in patients with autoimmune thyroid diseases (AITD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and ninety\u2010five patients with AITD (139 Hashimoto's thyroiditis (HT) patients and 56 Graves' disease (GD) patients) and 90 healthy blood donors (HBD) were studied. IgG, IgA and IgM aCL and a\u03b22GPI were determined by ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred fifty\u2010four AITD patients were women and 41 were men. Fifty\u2010six healthy subjects were women and 34 were men. The median age of patients and the control group was 45 and 38.5\u2009years, respectively. The frequency of aPL was significantly higher in patients with AITD and in patients with HT than in HBD (33.3% vs 11.1%, <jats:italic>p<\/jats:italic>\u2009&lt;\u200910<jats:sup>\u22123<\/jats:sup> and 38.1% vs 11.1%, <jats:italic>p<\/jats:italic>\u2009&lt;\u200910<jats:sup>\u22123<\/jats:sup>). The frequency of aPL in GD was significantly lower than in HT (21.4% vs 38.1%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.025). In patients with HT, a\u03b22GPI (34.5%) was significantly more frequent than aCL (13.6%) (<jats:italic>p<\/jats:italic>\u2009&lt;\u200910<jats:sup>\u22123<\/jats:sup>). The frequency of a\u03b22GPI was significantly higher in patients with HT than in healthy population (34.5% vs 11.1%, <jats:italic>p<\/jats:italic>\u2009&lt;\u200910<jats:sup>\u22123<\/jats:sup>). In HT patients, IgA isotype of a\u03b22GPI was significantly more common than in HBD and in GD patients (27.3% vs 7.8%, <jats:italic>p<\/jats:italic>\u2009&lt;\u200910<jats:sup>\u22123<\/jats:sup> and 27.3% vs 12.5%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>a\u03b22GPI and not aCL were frequent in AITD. IgA was the predominant isotype of a\u03b22GPI. a\u03b22GPI\u2010IgA was more frequent in HT than in GD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24788","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T14:25:06Z","timestamp":1669386306000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Antiphospholipid antibodies in autoimmune thyroid diseases"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2520-9508","authenticated-orcid":false,"given":"Amani","family":"Manka\u00ef","sequence":"first","affiliation":[{"name":"Laboratory of Immunology Farhat Hached Hospital  Sousse Tunisia"},{"name":"High School of Sciences and Techniques of Health Tunis El Manar University  Tunis Tunisia"},{"name":"Research Unit \"Obesity: Etiopathology and Treatment, UR18ES01\" National Institute of Nutrition and Food Technology  Tunis 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