{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T22:13:13Z","timestamp":1778883193949,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005315","name":"Natural Science Foundation of Ningbo Municipality","doi-asserted-by":"publisher","award":["2019A610237"],"award-info":[{"award-number":["2019A610237"]}],"id":[{"id":"10.13039\/501100005315","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LBY22H180004"],"award-info":[{"award-number":["LBY22H180004"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Numerous studies have described the critical importance of interleukin (IL) \u201036\u03b3 in host defense against lung infections, but it is unknown whether it plays a role in infectious pleural effusion (IPE). This study aimed to examine the levels of IL\u201036\u03b3 in pleural effusions of different etiologies and evaluate the diagnostic accuracy of IL\u201036\u03b3 in the differential diagnosis of IPE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 112 individuals was enrolled in this research. IL\u201036\u03b3 levels in pleural fluids of all 112 patients were measured by enzyme\u2010linked immunosorbent assay (ELISA). We also characterized these markers' diagnostic values across various groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with tuberculous pleural effusion (TPE) and parapneumonic effusion (PPE) had exhibited markedly higher IL\u201036\u03b3 levels in their pleural fluid than the malignant pleural effusion (MPE) and transudative effusion patients. Furthermore, the IL\u201036\u03b3 concentrations in TPE patients were evidently higher than in uncomplicated parapneumonic effusion (UPPE) patients but significantly lower than in complicated parapneumonic effusion (CPPE)\/empyema patients. Pleural fluid IL\u201036\u03b3 is a useful marker to differentiate TPE from UPPE, at a cut\u2010off value for 657.5\u00a0pg\/ml (area under the curve\u00a0=\u00a00.904, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) with 70.0% sensitivity and 95.7% specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The elevated IL\u201036\u03b3 in pleural effusion may be used as a novel biomarker for infectious pleural effusion diagnosis, particularly in patients with CPPE\/empyema, and is a potentially promising biomarker to differentiate between TPE and UPPE.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24799","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T20:19:26Z","timestamp":1670444366000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A novel biomarker for pleural effusion diagnosis: Interleukin\u201036\u03b3 in pleural fluid"],"prefix":"10.1002","volume":"37","author":[{"given":"Lun","family":"Guo","sequence":"first","affiliation":[{"name":"School of Medicine Ningbo University  Ningbo China"},{"name":"Department of Pulmonary and Critical Care Medicine, The Affiliated Hospital of Medical School Ningbo University  Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qipan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Medicine Ningbo University  Ningbo China"},{"name":"Department of Pulmonary and Critical Care Medicine, The Affiliated Hospital of Medical School Ningbo University  Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengna","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, The Affiliated Hospital of Medical School Ningbo University  Ningbo 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weili","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medicine Ningbo University  Ningbo China"},{"name":"Department of Pulmonary and Critical Care Medicine, The Affiliated Hospital of Medical School Ningbo University  Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaofen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of laboratory medicine Ningbo Ninth Hospital  Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6181-4548","authenticated-orcid":false,"given":"Qunli","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, The Affiliated Hospital of Medical School Ningbo University  Ningbo 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