{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:31:50Z","timestamp":1762432310887,"version":"3.41.2"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T00:00:00Z","timestamp":1671148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072371","82202584"],"award-info":[{"award-number":["82072371","82202584"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A wave of the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection has rapidly spread in Shanghai, China. Hematological abnormalities have been reported in coronavirus disease 2019 (COVID\u201019) patients; however, the difference in hematological parameters between COVID\u201019 patients with fever and patients who are febrile from other causes remains unexplored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study enrolled 663 SARS\u2010CoV\u20102 positive patients identified by RT\u2010PCR. Clinical parameters, including age, sex, and threshold cycle values of all COVID\u201019 patients, and hematological parameters of COVID\u201019 patients in the fever clinic were abstracted for analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 60.8% of COVID\u201019 patients were male, and the median age was 45\u2009years. Most of COVID\u201019 patients were asymptomatic, while 25.8% of patients showed fever and 10.9% of patients had other emergencies. COVID\u201019 patients with fever had significantly lower white blood cells (WBCs), neutrophils, lymphocytes, platelets and C\u2010reactive protein (CRP), and significantly higher monocyte\u2010to\u2010lymphocyte ratio (MLR), platelet\u2010to\u2010lymphocyte ratio (PLR), mean platelet volume (MPV), and mean platelet volume\u2010to\u2010platelet ratio (MPR) levels, compared with those in SARS\u2010CoV\u20102 negative patients with fever from other causes (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Neutrophil\u2010to\u2010lymphocyte ratio (NLR), PLR, and systemic inflammatory index (SII) levels were significantly higher in COVID\u201019 patients with emergencies (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). WBCs showed the best performance with an area under the curve (0.756), followed by neutrophils (0.730) and lymphocytes (0.694) in the diagnosis of COVID\u201019 in the fever clinic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>WBCs, neutrophils, lymphocytes, platelets, CRP and MLR, PLR, and MPR may be useful in early diagnosis of COVID\u201019 in the fever clinic.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24808","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T17:39:30Z","timestamp":1671212370000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hematological characteristics of <scp>COVID<\/scp>\u201019 patients with fever infected by the Omicron variant in Shanghai: A retrospective cohort study in China"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7796-0902","authenticated-orcid":false,"given":"Tingting","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Shanghai Changzheng Hospital, Naval Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Shanghai Changzheng Hospital, Naval Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuo","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Oncology Eastern Hepatobiliary Surgery Hospital, Naval Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liansheng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Shanghai Changzheng Hospital, Naval Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiafeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Shanghai Changzheng Hospital, Naval Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Shanghai Changzheng Hospital, Naval Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2549-2721","authenticated-orcid":false,"given":"Lin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Shanghai Changzheng Hospital, Naval Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04466-x"},{"volume-title":"Classification of Omicron (B.1.1.529): SARS\u2010CoV\u20102 Variant of Concern","year":"2021","author":"WHO","key":"e_1_2_9_3_1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.877101"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.24868"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00017-4"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00838-8"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12675"},{"issue":"3","key":"e_1_2_9_9_1","first-page":"417","article-title":"Mean platelet volume: an overlooked herald of malignant thyroid nodules","volume":"58","author":"Sit M","year":"2019","journal-title":"Acta Clin Croat"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.29271\/jcpsp.2018.11.844"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2022-0656"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa248"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.20-1536"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2217\/bmm-2020-0317"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h5527"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-1665"},{"issue":"4","key":"e_1_2_9_17_1","first-page":"566","article-title":"How to analyze tumor stage data in clinical research","volume":"7","author":"Hu ZD","year":"2015","journal-title":"J Thorac Dis"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2119658"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25774"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.912367"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2022.153782"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27524"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-020-0074-x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007214"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.825892"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25767"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.822556"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.916453"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40200-020-00595-0"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-022-02029-8"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-022-02725-5"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.960536"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000002219"},{"issue":"6","key":"e_1_2_9_34_1","first-page":"1945","article-title":"Bone mineral density (BMD) and neutrophil\u2010lymphocyte ratio (NLR), monocyte\u2010lymphocyte ratio (MLR), and platelet\u2010lymphocyte ratio (PLR) in childhood thyroid diseases","volume":"26","author":"Bala MM","year":"2022","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.936206"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/07435800.2022.2127757"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2015.1091136"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0262356"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2020-0658"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9060143"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-33373-3"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-014-0683-5"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/13685538.2019.1632283"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.4314\/ahs.v19i1.35"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1005697"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.63.12.1065"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2021.1950898"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25235725"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/hvaa200"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18684-2"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.24808","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcla.24808","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.24808","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T01:02:13Z","timestamp":1692666133000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.24808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,16]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/jcla.24808"],"URL":"https:\/\/doi.org\/10.1002\/jcla.24808","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"type":"print","value":"0887-8013"},{"type":"electronic","value":"1098-2825"}],"subject":[],"published":{"date-parts":[[2022,12,16]]},"assertion":[{"value":"2022-08-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e24808"}}