{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:02:17Z","timestamp":1771657337524,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T00:00:00Z","timestamp":1671408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004160","name":"Mazandaran University of Medical Sciences","doi-asserted-by":"publisher","award":["1327"],"award-info":[{"award-number":["1327"]}],"id":[{"id":"10.13039\/501100004160","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Aspergillus<\/jats:italic> endocarditis (AE) is a rare fatal infection. The infection is often reported in patients with prosthetic heart valves, immunosuppressed, broad\u2010spectrum antimicrobial use regimens, and drug abusers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Herein, we report a rare case of native mitral valve AE in a 63\u2010year\u2010old man, with a probable COVID\u201019\u2010associated invasive pulmonary aspergillosis nine months ago treated with antifungals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the last admission, the lethargy, neurological deficit, and septic\u2010embolic brain abscess in brain MRI led to suspicion of infective endocarditis. Transesophageal two\u2010dimensional echocardiography and color Doppler flow velocity mapping showed a large highly mobile mass destroying leaflet and severe mitral regurgitation. The Surgical valve replacement is performed. The surgical valve replacement is performed. Direct microscopic examination and culture of the explanted and vegetative mass revealed <jats:italic>Aspergillus<\/jats:italic> section <jats:italic>Fumiagati<\/jats:italic> confirmed by molecular method. Despite the administration of voriconazole and transient improvement the patient expired.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>As AE is a late consequence of COVID\u201019\u2010associated invasive pulmonary aspergillosis, therefore, long\u2010term follow\u2010up of invasive aspergillosis, and prompt diagnosis of surgical and systemic antifungal therapy treatment, are warranted to provide robust management.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24816","type":"journal-article","created":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T03:41:08Z","timestamp":1671507668000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<scp>Post\u2010COVID<\/scp>\u201019 fatal <i>Aspergillus<\/i> endocarditis: A case report"],"prefix":"10.1002","volume":"37","author":[{"given":"Narges","family":"Najafi","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Antimicrobial Resistance Research Center, Communicable Diseases Institute Mazandaran University of Medical Sciences  Ghaemshahr Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7324-7456","authenticated-orcid":false,"given":"Azam","family":"Moslemi","sequence":"additional","affiliation":[{"name":"Student Research Committee Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahman","family":"Ghafari","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Cardiovascular Research Center, Mazandaran Heart Center Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shadi","family":"Shayesteh Azar","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Antimicrobial Resistance Research Center, Communicable Diseases Institute Mazandaran University of Medical Sciences  Ghaemshahr Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Nabati","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine Cardiovascular Research Center Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Faeli","sequence":"additional","affiliation":[{"name":"Student Research Committee Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Salimi","sequence":"additional","affiliation":[{"name":"Student Research Committee Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roghayeh","family":"Mirzakhani","sequence":"additional","affiliation":[{"name":"Mazandaran Heart Center Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3094-8436","authenticated-orcid":false,"given":"Tahereh","family":"Shokohi","sequence":"additional","affiliation":[{"name":"Invasive Fungi Research Center, Communicable Diseases Institute Mazandaran University of Medical Sciences  Sari Iran"},{"name":"Department of Medical Mycology, School of Medicine Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-022-00621-0"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S258637"},{"issue":"8","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0201459","article-title":"Aspergillus endocarditis: diagnostic criteria and predictors of outcome, a retrospective cohort study","volume":"13","author":"Meshaal MS","year":"2018","journal-title":"PLoS One"},{"issue":"2","key":"e_1_2_10_5_1","first-page":"43","article-title":"Catastrophic Candida prosthetic valve endocarditis and COVID\u201019 comorbidity: a rare case","volume":"7","author":"Davoodi L","year":"2021","journal-title":"Curr Med Mycol"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.06.061"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof7110948"},{"key":"e_1_2_10_8_1","unstructured":"WayneP.Reference method for broth dilution antifungal susceptibility testing of yeasts approved standard. 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