{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T11:55:57Z","timestamp":1792756557040,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The accuracy of alpha\u2010fetoprotein (AFP) as a diagnostic marker for hepatocellular carcinoma (HCC) is insufficient, and the application of abnormal prothrombin (PIVKA\u2010II) in HCC is still controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Serum AFP and PIVKA\u2010II levels were analyzed in 145 cases of HCC, 57 of benign liver disease, 55 of cholangiocarcinoma and gallbladder carcinoma, 112 of other gastrointestinal tumors with liver metastasis, and 101 healthy controls. Receiver operating characteristic curve and area under the curve were used to evaluate the diagnostic value of AFP and PIVKA\u2010II for HCC. The changes in serum AFP and PIVKA\u2010II levels before and after treatment in 47 HCC patients who underwent surgery and 77 who received interventional treatment were used to evaluate treatment efficacy and prognosis in HCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The concentrations of AFP and PIVKA\u2010II in the HCC group were significantly higher than those in other groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). The diagnostic value of PIVKA\u2010II in HCC was better than that of AFP, and combined detection improved the diagnostic sensitivity and specificity. The levels of AFP and PIVKA\u2010II after liver cancer surgery were significantly lower than those before surgery. Elevated levels of PIVKA\u2010II before surgery predicted disease progression, and patients who remained positive for PIVKA\u2010II after surgery had worse prognosis than those who became negative after surgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Combined detection of AFP and PIVKA\u2010II is superior to both tests alone. We found that higher serum level of PIVKA\u2010II indicates more severe HCC, with worse prognosis, while the level of AFP had no correlation with the prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.24823","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T04:31:47Z","timestamp":1672288307000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Clinical value of serum\n                    <scp>AFP<\/scp>\n                    and\n                    <scp>PIVKA\u2010II<\/scp>\n                    for diagnosis, treatment and prognosis of hepatocellular carcinoma"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4223-1793","authenticated-orcid":false,"given":"Shan","family":"Tian","sequence":"first","affiliation":[{"name":"School of Laboratory Medicine and Life Science Wenzhou Medical University  Wenzhou Zhejiang China"},{"name":"Department of Clinical Laboratory Zhejiang Cancer Hospital  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongyi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Zhejiang Cancer Hospital  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Zhejiang Cancer Hospital  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Zhejiang Cancer Hospital  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21332"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.09.014"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15251"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-004-0552-0"},{"key":"e_1_2_10_6_1","first-page":"8868370","article-title":"The diagnostic value of serum PIVKA\u2010II alone or in combination with AFP in Chinese hepatocellular carcinoma patients","volume":"2022","author":"Xu F","year":"2021","journal-title":"Dis Markers"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2021.08.003"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.11413"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2010.02348.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000327577"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2016.00019"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.726213"},{"issue":"2","key":"e_1_2_10_13_1","first-page":"77","article-title":"The value of PIVKA\u2010 versus AFP for the diagnosis and detection of postoperative changes in hepatocellular carcinoma","volume":"4","author":"Lee Q","year":"2021","journal-title":"J Interv Med"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1247132"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00240-3"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14223"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(00)00539-5"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000005811"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgh3.12720"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.019"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30233"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/1010428317705763"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.5582\/ddt.2017.01036"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2004.10.003"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-08138-3"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep35050"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/1010428317720863"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000001652"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-021-02427-x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2022.01.007"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.833999"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.4291\/wjgp.v1.i4.129"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0251656"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-004-0398-0"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.24823","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcla.24823","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.24823","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T21:02:40Z","timestamp":1692651760000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.24823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,29]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/jcla.24823"],"URL":"https:\/\/doi.org\/10.1002\/jcla.24823","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,29]]},"assertion":[{"value":"2022-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e24823"}}