{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:43:09Z","timestamp":1790883789306,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T00:00:00Z","timestamp":1672617600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007224","name":"National Foundation for Science and Technology Development","doi-asserted-by":"publisher","award":["108.012018.316"],"award-info":[{"award-number":["108.012018.316"]}],"id":[{"id":"10.13039\/100007224","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Antioxidant genes, such as superoxide dismutase (<jats:italic>SOD<\/jats:italic>), catalase (<jats:italic>CAT<\/jats:italic>), and nitric oxide synthase (<jats:italic>NOS<\/jats:italic>), play critical roles in spermatogenesis and sperm functions. Polymorphisms of antioxidant genes have been shown to be strongly associated with sperm quality which affects male fertility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To investigate the association of antioxidant gene polymorphisms to male infertility in Vietnamese men, in this case\u2013control study, using Sanger sequencing, we genotyped four variants <jats:italic>SOD1:<\/jats:italic>7958G&gt;A, <jats:italic>SOD2:<\/jats:italic>c.47T&gt;C, <jats:italic>CAT<\/jats:italic>:\u2010262C&gt;T, and <jats:italic>NOS3:<\/jats:italic>\u2010786C&gt;T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and Conclusions<\/jats:title><jats:p>We identified <jats:italic>SOD1:<\/jats:italic>7958GA genotype and <jats:italic>NOS3:<\/jats:italic>\u2010786CT genotype in the infertility group were significantly higher than in the control with OR\u00a0=\u00a02.191 (95% CI: 1.226\u20133.915, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.004) and OR\u00a0=\u00a03.135 (95% CI: 1.591\u20136.180, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), respectively. We also detected that the frequency of the <jats:italic>SOD2:<\/jats:italic>c.47TC genotype was significantly higher in the male infertility group than in fertile men (OR\u00a0=\u00a01.941, 95% CI: 1.063\u20133.595, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.029). Gene\u2013gene interactions between the SNPs of <jats:italic>SOD1<\/jats:italic>, <jats:italic>SOD2<\/jats:italic>, and <jats:italic>CAT<\/jats:italic> might increase the risk of male infertility patients. In particular, patients carrying the <jats:italic>SOD1<\/jats:italic>:GA+AA, <jats:italic>SOD2<\/jats:italic>:TC+CC, and <jats:italic>CAT<\/jats:italic>:CT\/TT genotype pattern have an increased risk of male infertility (OR\u00a0=\u00a07.614, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.007). To our knowledge, this is the first study to evaluate the association between the <jats:italic>SOD1<\/jats:italic>:7958G&gt;A polymorphism and male infertility. Further studies with larger sample sizes and more genes are needed to better assess the association between variants of antioxidant genes and male infertility.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24829","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T01:39:05Z","timestamp":1672709945000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Genetic variations of antioxidant genes and their association with male infertility in Vietnamese men"],"prefix":"10.1002","volume":"37","author":[{"given":"Huy Anh","family":"Bach","sequence":"first","affiliation":[{"name":"Institute of Genome Research (IGR), Vietnam Academy of Science and Technology (VAST)  Hanoi Vietnam"},{"name":"Graduated University of Science and Technology, Vietnam Academy of Science and Technology (VAST)  Hanoi Vietnam"},{"name":"The Hospital of Post and Telecommunications  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuong Nhung","family":"Vu","sequence":"additional","affiliation":[{"name":"Institute of Genome Research (IGR), Vietnam Academy of Science and Technology (VAST)  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Huyen Thuong","family":"Ma","sequence":"additional","affiliation":[{"name":"Institute of Genome Research (IGR), Vietnam Academy of Science and Technology (VAST)  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai Ha","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Institute of Genome Research (IGR), Vietnam Academy of Science and Technology (VAST)  Hanoi Vietnam"},{"name":"Graduated University of Science and Technology, Vietnam Academy of Science and Technology (VAST)  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phan","family":"Tran\u00a0Duc","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Genetics Hanoi Medical University  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duc","family":"Bui\u00a0Minh","sequence":"additional","affiliation":[{"name":"Institute of Genome Research (IGR), Vietnam Academy of Science and Technology (VAST)  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van Hai","family":"Nong","sequence":"additional","affiliation":[{"name":"Institute of Genome Research (IGR), Vietnam Academy of Science and Technology (VAST)  Hanoi Vietnam"},{"name":"Graduated University of Science and Technology, Vietnam Academy of Science and Technology (VAST)  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0182-8996","authenticated-orcid":false,"given":"Dang 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