{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T17:52:35Z","timestamp":1793555555748,"version":"4.5.0"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2020J05285"],"award-info":[{"award-number":["2020J05285"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Backgrounds<\/jats:title><jats:p>Human epididymis protein\u20104 (HE\u20104) is a commonly used biomarker for diagnosing ovarian cancer. Elevated HE\u20104 has also been observed in various benign conditions including chronic kidney disease (CKD); however, generalizability and statistical power of previous studies have been limited by small sample sizes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We conducted a retrospective study that included 80 pathologically confirmed ovarian cancer patients, 641 CKD patients, and 2661 healthy controls. Serum HE\u20104 and several renal function parameters were collected and compared between the three groups. Correlation analysis was conducted to evaluate the relationship between HE\u20104 and renal function parameters. A receiver operating characteristic curve was established to evaluate its diagnostic performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CKD patients had the highest levels of HE\u20104, with a median of 193.00\u2009pmol\/L, while the median in ovarian cancer patients was 90.82\u2009pmol\/L. HE\u20104 levels also increased with CKD progression, and Spearman's rank correlation showed that HE\u20104 had a strong correlation with renal function parameters in CKD patients. Furthermore, HE\u20104 exhibited a satisfactory diagnostic performance in both differentiating CKD patients and controls as well as stage 2 CKD patients and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HE\u20104 can be used as an alternative biomarker for diagnosing CKD as it is less affected by several preanalytical factors. Nevertheless, in clinical practice, elevated HE\u20104 requires taking\u00a0both\u00a0CKD and ovarian cancer into consideration.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24847","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T04:56:23Z","timestamp":1675918583000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Significantly elevated serum human epididymis protein\u20104 in chronic kidney disease patients without ovarian cancer: A large\u2010scale retrospective study"],"prefix":"10.1002","volume":"37","author":[{"given":"Shuidi","family":"Yan","sequence":"first","affiliation":[{"name":"Clinical Laboratory, Zhongshan Hospital Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5120-8221","authenticated-orcid":false,"given":"Yong","family":"Lin","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Zhongshan Hospital Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1346-3146","authenticated-orcid":false,"given":"Xuelin","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Emergency, Zhongshan Hospital Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod45.2.350"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(99)00342-X"},{"key":"e_1_2_8_4_1","first-page":"3695","article-title":"The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma","volume":"63","author":"Hellstr\u00f6m I","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gore.2018.07.002"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/352670"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800612"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2020.12.029"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.230"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013060604"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2012-0097"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1258\/acb.2011.011258"},{"issue":"3","key":"e_1_2_8_13_1","first-page":"1","article-title":"Clinical practice guideline for the evaluation and management of chronic kidney disease","volume":"2013","author":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO","year":"2012","journal-title":"Kidney Int"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2010.03.026"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11682"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2989"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/labmed\/lmx036"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.24847","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcla.24847","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.24847","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:47:38Z","timestamp":1692665258000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.24847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/jcla.24847"],"URL":"https:\/\/doi.org\/10.1002\/jcla.24847","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"2022-11-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e24847"}}