{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:59:46Z","timestamp":1793109586868,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>The burden of HPV varies by country and HIV status. The study aimed to evaluate HPV types prevalent in HIV\u2010positive females compared with HIV\u2010negative females in the local population of the federal capital territory in Pakistan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>The selected female population consisted of 65 already diagnosed HIV\u2010positive females and 135 HIV\u2010negative females. Cervical scrap was collected and analyzed for HPV and cytology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The prevalence of HPV in HIV\u2010positive patients was 36.9%, higher than HIV\u2010negative patients (4.4%). 12.30% had cervical cytology interpreted as \u201cLSIL\u201d and 87.69% had cytology interpreted as \u201cNIL.\u201d The high\u2010risk type was detected in 15.39% while 21.54% showed low\u2010risk HPV types. Among the high\u2010risk types, HPV18 (6.15%), HPV16 (4.62%), HPV45 (3.07%), HPV33 (1.53%), HPV58 (3.07%), and HPV68 (1.53%) were found. In patients with LSIL, high\u2010risk HPV accounts for 62.5%. Risk factors, such as age, marital status, educational status, residence, parity, other STDs, and contraceptives, were analyzed to find the correlation with HPV infection Age \u226435\u2009years (OR 1.21, 95% CI, 0.44\u20133.34), illiterate and incomplete secondary education (OR 1.08, 95% CI, 0.37\u20133.15), and those reported not to use contraceptives (OR: 1.90; 95% CI: 0.67\u20135.42) have an association for increased risk of HPV infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HPV18, HPV16, HPV58, HPV45, HPV68, and HPV33 were identified among high\u2010risk HPV types. High\u2010risk HPV was detected in 62.5% of low\u2010grade squamous intraepithelial lesions. The data is useful for health policymakers to develop a strategy for HPV screening and prophylactic vaccination to prevent cervical cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.24851","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T21:50:05Z","timestamp":1676670605000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Prevalence of HPV types in HIV\u2010positive and negative females with normal cervical cytology or dysplasia"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2650-6291","authenticated-orcid":false,"given":"Hafsa","family":"Aziz","sequence":"first","affiliation":[{"name":"Nuclear Medicine, Oncology and Radiotherapy Institute  Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Areej A.","family":"Sattar","sequence":"additional","affiliation":[{"name":"International Islamic University  Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humera","family":"Mahmood","sequence":"additional","affiliation":[{"name":"Nuclear Medicine, Oncology and Radiotherapy Institute  Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shazia","family":"Fatima","sequence":"additional","affiliation":[{"name":"Nuclear Medicine, Oncology and Radiotherapy Institute  Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Khurshid","sequence":"additional","affiliation":[{"name":"Pakistan Institute of Medical Sciences  Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Faheem","sequence":"additional","affiliation":[{"name":"Nuclear Medicine, Oncology and Radiotherapy Institute  Islamabad Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70230-8"},{"issue":"5","key":"e_1_2_9_3_1","article-title":"High\u2010risk oncogenic HPV genotype infection associates with increased immune activation and T cell exhaustion in ART\u2010suppressed HIV\u20101\u2010infected women","volume":"5","author":"Papasavvas E","year":"2016","journal-title":"Onco Targets Ther"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/692012"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm4040579"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/v6072762"},{"issue":"3","key":"e_1_2_9_7_1","first-page":"493","article-title":"Cervical cancer screening and HPV genotype distribution among asymptomatic patients of Karachi Pakistan","volume":"31","author":"Shahid M","year":"2015","journal-title":"Pak J Med Sci"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.47391\/JPMA.4166"},{"issue":"10","key":"e_1_2_9_9_1","first-page":"1992","article-title":"The 2001 Bethesda system terminology","volume":"68","author":"Apgar BS","year":"2003","journal-title":"Am Fam Physician"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2217\/fvl.15.94"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix135"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176422"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2881-1"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443610500294599"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.5144\/0256-4947.2019.403"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-5916.178614"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2015.02.018"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2017.11.009"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(00)00125-6"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit181"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021641"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800316"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.olq.0000204545.89516.0a"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605224"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2012.02.013"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103864"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.24851","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcla.24851","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.24851","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T20:47:34Z","timestamp":1692650854000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.24851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/jcla.24851"],"URL":"https:\/\/doi.org\/10.1002\/jcla.24851","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"2022-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e24851"}}