{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T22:03:31Z","timestamp":1783548211081,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T00:00:00Z","timestamp":1678060800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Inflammatory cytokines are implicated in the development of atherosclerosis and cardiomyocyte injury during acute myocardial infarction (AMI). This study aimed to investigate the correlation of eight common inflammatory cytokines with major adverse cardiac event (MACE) risk and further establish a prognostic model in AMI patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum samples of 210 AMI patients and 20 angina pectoris patients were, respectively, collected at admission, to detect tumor necrosis factor\u2010alpha (TNF\u2010\u03b1), interleukin (IL)\u20101\u03b2, IL\u20106, IL\u20108, IL\u201010, IL\u201017A, vascular cell adhesion molecule\u20101 (VCAM\u20101), and intercellular adhesion molecule 1 (ICAM\u20101) via enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TNF\u2010\u03b1, IL\u20106, IL\u20108, IL\u201017A, VCAM\u20101, and ICAM\u20101 were elevated (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.050); IL\u201010 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.009) was declined; IL\u20101\u03b2 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.086) was not varied in AMI patients compared with angina pectoris patients. TNF\u2010\u03b1 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.008), IL\u201017A (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.003), and VCAM\u20101 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.014) were elevated in patients with MACE occurrence compared to patients without MACE occurrence; meanwhile, they possessed a relatively good value for identifying MACE risk via receiver\u2010operating characteristic (ROC) analysis. Subsequent multivariate logistic regression analysis revealed that the independent risk factors for MACE contained TNF\u2010\u03b1 (odds ratio (OR)\u00a0=\u00a01.038, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), IL\u20101\u03b2 (OR\u00a0=\u00a01.705, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.044), IL\u201017A (OR\u00a0=\u00a01.021, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.009), history of diabetes mellitus (OR\u00a0=\u00a04.188, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.013), history of coronary heart disease (OR\u00a0=\u00a03.287, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.042), and symptom\u2010to\u2010balloon time (OR\u00a0=\u00a01.064, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.030), whose combination disclosed a satisfying prognostic value for MACE risk (area under the curve: 0.877, 95% CI: 0.817\u20130.936).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Elevated levels of serum TNF\u2010\u03b1, IL\u20101\u03b2, and IL\u201017A independently correlated with MACE risk in AMI patients, which perhaps provide novel auxiliary for AMI prognostic prediction.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24853","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T18:43:31Z","timestamp":1678128211000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Circulating tumor necrosis factor\u2010\u03b1, interleukin\u20101\u03b2, and interleukin\u201017A estimates increased major adverse cardiac event risk in acute myocardial infarction patients"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4200-9826","authenticated-orcid":false,"given":"Jing","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Cardiology HanDan Central Hospital  Handan 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