{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:31:01Z","timestamp":1759336261968,"version":"3.41.2"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T00:00:00Z","timestamp":1679270400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>COVID\u201019\u2010related immune responses in patients with end\u2010stage renal disease (ESRD) are characterized in detail by the humoral response, but their cellular immunity has not been clarified. Here, we evaluated virus\u2010specific T cells in parallel with serology\u2010related tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, 104 ESRD patients at the hemodialysis ward of Imam Reza hospital at Tabriz (Iran) were enrolled. After blood sampling, SARS\u2010CoV2\u2010specific humoral and cellular immune responses were evaluated by SARS\u2010CoV2\u2010specific IgM\/IgG ELISA and peptide\/MHCI\u2010Tetramers flow cytometry, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results showed that 14 (13.5%) and 45 (43.3%) patients had specific SARS\u2010CoV2 IgM and IgG in their sera, respectively. Immunophenotyping for SARS\u2010CoV2\u2010specific CD8<jats:sup>+<\/jats:sup> T lymphocytes revealed that 68 (65.4%) patients had these types of cells. Among SARS\u2010CoV2\u2010specific CD8<jats:sup>+<\/jats:sup> T lymphocytes positive subjects, 13 and 43 individuals had positive results for specific SARS\u2010CoV2 IgM and IgG existence, respectively. Also, there was a relationship between specific SARS\u2010CoV2 IgM (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.031) and IgG (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) existence and having SARS\u2010CoV2\u2010specific TCD8<jats:sup>+<\/jats:sup> lymphocytes in the studied population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite not having clinical symptoms, a high rate of SARS\u2010CoV2\u2010specific T\u2010cell response in asymptomatic ESRD patients may reveal a high burden of asymptomatic COVID\u201019 infection in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24863","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T04:18:58Z","timestamp":1679372338000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Potent <scp>SARS\u2010CoV2<\/scp>\u2010specific T\u2010cell response in asymptomatic hemodialysis patients with hidden <scp>COVID<\/scp>\u201019 infection history"],"prefix":"10.1002","volume":"37","author":[{"given":"Jalal","family":"Etemadi","sequence":"first","affiliation":[{"name":"Kidney Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roza","family":"Motavalli","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Faculty of Advanced Medical Sciences Tabriz University of Medical Sciences  Tabriz Iran"},{"name":"Student Research Committee Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Alireza","family":"Mirghaffari","sequence":"additional","affiliation":[{"name":"Kidney Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Sadegh","family":"Soltani\u2010Zangbar","sequence":"additional","affiliation":[{"name":"Student 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