{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:46:59Z","timestamp":1786978019177,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T00:00:00Z","timestamp":1682380800000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The management of hospitalized COVID\u201019 patients depends largely on controlling the intensified inflammatory response known as the cytokine storm. Candidate inflammatory cytokines can serve as new biomarkers for the management of hospitalized COVID\u201019 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients (80) were recruited into three groups: room air (RA), oxygen (OX) and mechanical ventilator (MV). Blood analysis was performed for RBC, WBC, Hb, Platelets, serum albumin and creatinine, INR, PTT, and hematocrit. ELISA was used to quantify a panel of inflammatory mediators including GM\u2010SCF, IFN\u2010\u03b1, IFN\u03b3, IL\u20101\u03b2, IL\u20101R, IL\u20102, IL\u20102Ra, IL\u20106, IL\u20108, IL\u201010, IL\u201012p70, IL\u201013, MCP\u20101, MIP\u20101a, and TNF\u2010\u03b1. Correlations between laboratory results and the levels of circulating inflammation mediators were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients on MV had low RBC, Hb, albumin, and HCT and high WBC count, PTT, and INR when compared to RA and OX groups. A statistical positive correlation was found between WBC and the levels of IL\u20106 and MCP\u20101. RBCs correlated negatively with IL\u20106 and IL\u201010 and positively with IL\u20108. Higher TNF\u2010\u03b1 correlated with lower platelet counts while higher levels of IL\u20101R\u03b1 and IL\u201010 were associated with lower Hb levels. Increases in IFN\u2010\u03b3 and TNF\u2010\u03b1 were indicative of compromised kidney functions as creatinine levels increased significantly. Most significant correlations were found between IL\u20106 and lab results, showing positive correlation with WBC and INR, and negative correlation with RBC, albumin, and HCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Having the most significant correlations, IL\u20106 high levels in mechanically ventilated patients were shown to affect laboratory results, and, therefore, is suggested as a severity biomarker of COVID\u201019.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.24881","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T06:12:07Z","timestamp":1682403127000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["<scp>IL<\/scp>\n                    \u20106 at the center of cytokine storm: Circulating inflammation mediators as biomarkers in hospitalized\n                    <scp>COVID<\/scp>\n                    \u201019 patients"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8675-0838","authenticated-orcid":false,"given":"Hossein M.","family":"Elbadawy","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy Taibah University  Madinah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Khattab","sequence":"additional","affiliation":[{"name":"Ohud Hospital  Madinah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina S.","family":"El\u2010Agamy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy Taibah University  Madinah Saudi Arabia"},{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba M.","family":"Eltahir","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy Taibah University  Madinah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisha","family":"Alhaddad","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy Taibah University  Madinah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahad Dakilallah","family":"Aljohani","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Ohud Hospital  Madinah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarraji Mohammed","family":"Almuzaini","sequence":"additional","affiliation":[{"name":"Department of Nursing Ohud Hospital  Madinah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mekky M.","family":"Abouzied","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy Taibah University  Madinah Saudi Arabia"},{"name":"Department of Biochemistry, Faculty of Pharmacy Minia University  Minia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Aldhafiri","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy Taibah University  Madinah Saudi 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