{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T10:56:00Z","timestamp":1769252160671,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,14]],"date-time":"2023-05-14T00:00:00Z","timestamp":1684022400000},"content-version":"vor","delay-in-days":43,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mucormycosis is a life\u2010threatening invasive fungal infection in immunocompromised and COVID\u201019 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Report<\/jats:title><jats:p>Here, we report a fatal rhino\u2010orbito\u2010cerebral mucormycosis caused by <jats:italic>Lichtheimia ramosa,<\/jats:italic> in a 79\u2010year\u2010old diabetic female. She was initially admitted to the hospital for COVID\u201019 infection and received broad\u2010spectrum antibiotics and corticosteroids. After 1\u2009month, she was admitted again because of persistent headaches and decreased right eye movement when the computed tomography scan showed mucosal thickening and opacification of paranasal sinuses. Microbiological investigations, including culture and direct microscopy, and histopathological findings confirmed the diagnosis of proven mucormycosis. The isolated causal agent was identified as <jats:italic>Lichtheimia ramosa<\/jats:italic> by sequencing the entire ITS region of nuclear ribosomal DNA. Despite surgical debridement and administration of liposomal amphotericin B 5\u2009mg\/kg\/day, the patient's level of consciousness suddenly deteriorated; she was intubated and mechanically ventilated in the ICU and died on the same day.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To our knowledge, this is the first worldwide case of COVID\u201019\u2010associated rhino\u2010orbito\u2010cerebral mucormycosis due to <jats:italic>Lichtheimia ramosa<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24895","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T03:30:30Z","timestamp":1684121430000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A case of <scp>COVID<\/scp>\u201019\u2010associated mucormycosis due to <i>Lichtheimia ramosa<\/i>"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0178-4372","authenticated-orcid":false,"given":"Shima","family":"Aboutalebian","sequence":"first","affiliation":[{"name":"Department of Medical Parasitology and Mycology, School of Medicine Isfahan University of Medical Sciences  Isfahan Iran"},{"name":"Mycology Reference Laboratory, Research Core Facilities Laboratory Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahzad","family":"Erami","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, School of Medicine, Shahid Beheshti Hospital Kashan University of Medical Sciences  Kashan Iran"},{"name":"Department of Medical Parasitology and Mycology, School of Public Health Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mansooreh","family":"Momen\u2010Heravi","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, School of Medicine, Shahid Beheshti Hospital Kashan University of Medical Sciences  Kashan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arezoo","family":"Charsizadeh","sequence":"additional","affiliation":[{"name":"Immunology, Asthma, and Allergy Research Institute Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Jamal Hashemi","family":"Hezaveh","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology and Mycology, School of Public Health Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir Hassan","family":"Matini","sequence":"additional","affiliation":[{"name":"Department of Pathology and Histology, School 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