{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:48:40Z","timestamp":1788281320679,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"9-10","license":[{"start":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T00:00:00Z","timestamp":1685923200000},"content-version":"vor","delay-in-days":35,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500685"],"award-info":[{"award-number":["81500685"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670804"],"award-info":[{"award-number":["81670804"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Elevated follicle\u2010stimulating hormone (FSH) is associated with an increased risk of postmenopausal osteoporosis. This study investigated the association of serum FSH with bone turnover markers (BTMs) and bone mineral density (BMD) in healthy women undergoing menopausal transition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 487 healthy women (age 35\u201365\u2009years, 50\u2009\u00b1\u20098.5\u2009years) were enrolled in this study. Serum FSH, BTMs, and BMD at lumbar spine and total hip were measured in these subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Follicle\u2010stimulating hormone was positively correlated with various BTMs (<jats:italic>r<\/jats:italic>\u2009=\u20090.339\u20130.583, all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and negatively correlated with lumbar spine and total hip BMD (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.629 and \u22120.514, all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). After adjusting for age and body mass index, the partial correlation coefficients of FSH with BTMs and BMD remained significant. Estimating from the regression equation, for every 10\u2009IU\/L increase in serum FSH, BTMs increased by 0.38\u20133.6 units, and BMD decreased by 0.03\u20130.05\u2009g\/cm<jats:sup>2<\/jats:sup>, respectively. Multiple linear regression analysis showed that FSH was a positive factor for serum bone\u2010specific alkaline phosphatase, osteocalcin, and N\u2010telopeptide of collagen type 1 (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.188\u20130.403, all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and a negative factor for lumbar spine BMD and serum C\u2010telopeptide of collagen type 1 (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.629 and \u20130.183, all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study suggests that serum FSH levels are an independent risk factor for BTMs and BMD in menopause\u2010transitioning women, particularly for serum BAP and lumbar spine BMD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24899","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T02:01:44Z","timestamp":1686103304000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association of follicle\u2010stimulating hormone with bone turnover markers and bone mineral density in Chinese women across the menopausal transition"],"prefix":"10.1002","volume":"37","author":[{"given":"Lin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Metabolism and Endocrinology, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases The Second Xiangya Hospital of Central South University  Changsha China"},{"name":"Department of Endocrinology and Metabolism, The Affiliated Changsha Hospital of Xiangya School of Medicine Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin\u2010Zhen","family":"Pi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Affiliated Changsha Hospital of Xiangya School of Medicine Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Metabolism and Endocrinology, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru\u2010Chun","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Metabolism and Endocrinology, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling\u2010Qing","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Metabolism and Endocrinology, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Feng","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Metabolism and Endocrinology, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases The Second Xiangya Hospital of Central South University  Changsha 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