{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T03:54:19Z","timestamp":1775188459517,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"9-10","license":[{"start":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T00:00:00Z","timestamp":1687478400000},"content-version":"vor","delay-in-days":53,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To investigate the correlation between brachial artery flow\u2010mediated endothelium\u2010dependent dilation (FMD) and platelet\u2013lymphocyte ratio (PLR) in peripheral blood and coronary atherosclerosis in diabetic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010five diabetic patients aged 62\u2009\u00b1\u20099\u2009years, 68% male and 32% female, who underwent brachial artery endothelial function test and coronary CT scan were collected. Coronary artery calcification (CAC) was observed to assess the presence of coronary atherosclerosis, and high\u2010resolution extravascular ultrasound was used to detect FMD. Platelet count and lymphocyte count were recorded by routine blood tests, and PLR was calculated for each study subject. Statistical methods were used to verify the association of FMD and PLR with CAC assessed by CT, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with coronary atherosclerosis had decreased FMD and increased PLR compared with patients with normal coronary arteries. Univariate logistic regression analysis showed that CAC score was significantly associated with both FMD (odds ratio: 0.167; 95% confidence interval: 0.049\u20130.565; <jats:italic>p<\/jats:italic>\u2009=\u20090.002) and PLR (odds ratio: 0.127; 95% confidence interval: 0.033\u20130.484; <jats:italic>p<\/jats:italic>\u2009=\u20090.001) at FMD\u2009&lt;\u20095.1% or PLR\u2009&gt;\u2009130. The area under the ROC curve of FMD and PLR alone was 0.760 and 0.763, respectively. In addition, combined diagnosis of FMD and PLR showed the highest area under the ROC curve (0.830).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>FMD combined with PLR is expected to be a precise diagnostic modality for coronary artery calcification in diabetic patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24935","type":"journal-article","created":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T01:03:37Z","timestamp":1687655017000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A study of the relationship between brachial artery vasodilation and platelet\/lymphocyte ratio in diabetic patients with coronary atherosclerosis"],"prefix":"10.1002","volume":"37","author":[{"given":"Meiling","family":"Wang","sequence":"first","affiliation":[{"name":"Ultrasound Department The Second Affiliated Hospital of Zhejiang Chinese Medical University  Hangzhou 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