{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T15:39:06Z","timestamp":1760369946927,"version":"3.41.2"},"reference-count":33,"publisher":"Wiley","issue":"17-18","license":[{"start":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T00:00:00Z","timestamp":1695600000000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074221"],"award-info":[{"award-number":["82074221"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of the study was to clarify the associations of HLA class I and II alleles with ankylosing spondylitis (AS) among Chinese Han.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed HLA genotyping and Sanger sequencing for 68 HLA\u2010B*27(\u2212), 62 HLA\u2010B*27(+) AS patients, and 70 controls. Case\u2013control analyses and separate analyses of HLA\u2010B*27(\u2212) patients were performed. One\u2010way ANOVA and Kruskal\u2013Wallis multiple comparisons test were used to analyze the effects of HLA\u2010A\\B\\C\\DRB1\\DQB1 alleles on clinical characteristics of HLA\u2010B*27(\u2212) and HLA\u2010B*27(+) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the HLA\u2010B*27(+) group, positive associations were seen with A*11:02, B*27:04, B*27:05, C*02:02, C*12:02, and DRB1*04:01 and negative associations were seen with A*33:03, B*07:02, B*57:01, and C*07:02. The age at onset was greater in HLA\u2010B*27(\u2212) patients than in HLA\u2010B*27(+) patients (30.03\u2009\u00b1\u200915.15 vs. 23.08\u2009\u00b1\u20097.79\u2009years). In the HLA\u2010B*27(\u2212) group, those with A*01:01, B*13:01, B*13:02, C*01:02, C*04:01, DQB1*02:01, DQB1*06:01, and DRB1*03:01 had an earlier onset than those without these alleles, while patients carrying B*40:02, C*07:02, C*12:02, C*15:02, DQB1*05:02, and DQB1*05:03 had a delayed onset. In the HLA\u2010B*27(\u2212) group, A*32:01(+), C*08:01(+), and DRB1*04:05(\u2212) women were likely to develop AS. In the HLA\u2010B*27(+) group, DQB1*03:02(+) women may be more likely to develop AS. DRB1*12:02 and HLA\u2010B*27 interacted with the distribution of AS\u2010affected sites. In the HLA\u2010B*27(+) group, DRB1*12:02(+) patients were likely to have peripheral joint involvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HLA class I and II alleles other than HLA\u2010B*27 contribute to AS predisposition and characteristics among Chinese Han patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24964","type":"journal-article","created":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T11:55:00Z","timestamp":1695642900000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Role of HLA class I and II alleles in susceptibility to ankylosing spondylitis in Chinese Han"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4974-0283","authenticated-orcid":false,"given":"Yongwei","family":"Jiang","sequence":"first","affiliation":[{"name":"Clinical Laboratory, China\u2010Japan Friendship Hospital  Beijing 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7096-2710","authenticated-orcid":false,"given":"Peng","family":"Gao","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoxiong","family":"Deng","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongtong","family":"Cao","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3226-4150","authenticated-orcid":false,"given":"Liang","family":"Ma","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, China\u2010Japan Friendship Hospital  Beijing 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