{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:22:44Z","timestamp":1790734964364,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"19-20","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prevalence of non\u2010alcoholic fatty liver disease (NAFLD) and obesity is worldwide on the rise. Body roundness index (BRI), as a newly developed anthropometric indicator, has been recently reported to identify obesity. However, it is still unclear whether BRI is associated with the prevalence of NAFLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were from the National Health and Nutrition Examination Survey (NHANES) 2017\u20132018. NAFLD was diagnosed based on hepatic steatosis defined by CAP values \u2265274\u2009dB\/m. Multivariable logistic regression analysis was performed to detect the association between BRI and the odds of NAFLD. Subgroup analysis stratified by age, gender, BMI, and race was further conducted. To explore the potential ability of BRI in predicting NAFLD, the area under the curve (AUC) of BRI was calculated by receiver operating characteristic (ROC) analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 4467 study participants, 1718 (38.5%) were diagnosed with NAFLD. Compared to the non\u2010NAFLD group, participants with NAFLD had a higher level of BRI. The positive associations between BRI and NAFLD were detected in all three models (mode 1: OR\u2009=\u20091.71, 95% CI: 1.65\u20131.78, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001; mode 2: OR\u2009=\u20091.78, 95% CI: 1.71\u20131.86, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001; mode3: OR\u2009=\u20091.23, 95% CI: 1.11\u20131.35, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). The positive association steadily existed in different subgroups after stratified by age, gender, and BMI. Moreover, the non\u2010linear association between BRI and NAFLD was detected, presenting inverted U\u2010shaped curves. Furthermore, BRI had a high predictive value (AUC\u2009=\u20090.807) in identifying NAFLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>BRI was positively associated with the prevalence of NAFLD among individuals in America, regardless of age, gender, and BMI. Besides, BRI presented a high ability for identifying NAFLD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24973","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T10:04:49Z","timestamp":1697623489000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Association between body roundness index and non\u2010alcoholic fatty liver disease detected by Fibroscan in America"],"prefix":"10.1002","volume":"37","author":[{"given":"Ningning","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine The Second Hospital of Ninghai City, Chengguan Hospital of Ninghai City  Ningbo Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengguo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Infection the Third Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang 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