{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T14:29:34Z","timestamp":1778077774773,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"21-22","license":[{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970601"],"award-info":[{"award-number":["81970601"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200850"],"award-info":[{"award-number":["82200850"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adrenocortical carcinoma (ACC) is an aggressive and rare malignant tumor associated with poor outcomes. Cuproptosis, a new pattern of cell death, relies on mitochondrial respiration and is associated with protein lipoylation. Increasing evidence has demonstrated the potential roles of cuproptosis in several tumor entities. However, the relationship between cuproptosis and ACC remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 10 cuproptosis\u2010related genes (CRGs) of patients with ACC were obtained from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases and differential expression analysis of CRGs was analyzed. Functional enrichment of the CRGs was performed and protein\u2013protein interaction analysis was utilized to explore the association between the CRGs. Cuproptosis\u2010related risk score (CRRS) was constructed by Lasso Cox regression and validated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the current study, the alteration and expression patterns of 10 CRGs in TCGA\u2013ACC datasets were analyzed. We identified different expression patterns of CRGs in ACCs, discovered strong associations between CRGs and ACCs, and found that the CRGs were associated with immune infiltration in ACCs. A CRRS was created thereafter to predict overall survival (OS). CRRS\u2009=\u2009(0.083103718) *FDX1\u2009+\u2009(\u22120.278423862) *LIAS+(0.090985682) *DLAT+(\u22120.018784047) *PDHA1\u2009+\u2009(0.297218951) *MTF1\u2009+\u2009(0.310197964) *CDKN2A. Patients were divided into high\u2010 and low\u2010risk groups based on their CRRS, and independent prognostic factors were investigated. Finally, CDKN2A and FDX1 were found to be independent prognostic predictors of patients with ACC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CDKN2A and FDX1 are independent prognostic predictors of patients with ACC. Cuproptosis may play a role in the development of ACC, providing a new perspective on therapeutic strategies related to CRGs for cancer prevention and treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24981","type":"journal-article","created":{"date-parts":[[2023,11,25]],"date-time":"2023-11-25T01:32:06Z","timestamp":1700875926000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A novel cuproptosis\u2010related prognostic gene signature in adrenocortical carcinoma"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2272-1813","authenticated-orcid":false,"given":"Wenjun","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Urology The Second Affiliated Hospital, School of Medicine, Zhejiang University  Hangzhou Zhejiang 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