{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:56:07Z","timestamp":1753869367628,"version":"3.41.2"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Three\u2010part differential (3PD) haematology analysers offer a quick, easy\u2010to\u2010use and economical way to acquire important information about a patient's physiology. In this study, we evaluated a new 3PD analyser, the Sysmex XQ\u2010320, investigated its comparability with its predecessor (Sysmex XP\u2010300) and the five\u2010part differential analyser Sysmex XN\u20109000, and explored its flagging potential.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Analytical performance studies were conducted for repeatability, within\u2010laboratory precision, between\u2010day precision, carry\u2010over and linearity with fresh blood and QC material. Method comparison was performed in 493 samples comparing XQ\u2010320 with XP\u2010300, using the XN\u20109000 as the gold standard.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The XQ\u2010320 excelled manufacturer's specifications in the analytical performance studies, except for MXD in within\u2010laboratory and between\u2010day precisions using the QC material level 1. The XQ\u2010320 showed correlation values greater than 0.94 with XN\u20109000 for the majority of the 20 reportable parameters (MXD# 0.891, MXD% 0.898 and MCHC 0.849). Improvements over the XP\u2010300 were observed in WBC in the leucocytopenic range (bias \u22120.038 vs. \u22120.097) and PLT (bias 2.568 vs. \u22127.877, intercept 3.880 vs. \u22128.845). Concordance between XQ\u2010320 and XP\u2010300 was 91.9% for the WBC histogram abnormal distribution flag and 95.3% for the PLT flag. Patterns of increased neutrophils and decreased mixed cells on the XQ\u2010320 were observed in samples that raised a flag on XN\u20109000.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The XQ\u2010320 showed excellent analytical performance, and very good to excellent correlation with XN\u20109000 with improvements over XP\u2010300. Flagging combined with parameter patterns identified additional suspected abnormal samples, thus making the XQ\u2010320 an excellent solution for laboratories utilising 3PD analysers.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.25017","type":"journal-article","created":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T05:19:25Z","timestamp":1708751965000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the Sysmex XQ\u2010320 three\u2010part differential haematology analyser and its flagging capabilities"],"prefix":"10.1002","volume":"38","author":[{"given":"Christine","family":"Coutaz","sequence":"first","affiliation":[{"name":"General Haematology Laboratory Centre Hospitalier Universitaire Vaudois (CHUV)  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrien","family":"Mamin","sequence":"additional","affiliation":[{"name":"General Haematology Laboratory Centre Hospitalier Universitaire Vaudois (CHUV)  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5217-4592","authenticated-orcid":false,"given":"Konstantinos","family":"Mintzas","sequence":"additional","affiliation":[{"name":"Sysmex Europe SE  Norderstedt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,23]]},"reference":[{"issue":"3","key":"e_1_2_9_2_1","first-page":"107","article-title":"Enhancing the clinical value of medical laboratory testing","volume":"38","author":"Sikaris KA","year":"2017","journal-title":"Clin Biochem Rev"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cll.2014.10.007"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/JLP.JLP_124_17"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12522"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.13793"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12201"},{"volume-title":"EP15\u2010A3 User Verification of Precision and Estimation of Bias; Approved Guideline","year":"2014","author":"CLSI","key":"e_1_2_9_8_1"},{"key":"e_1_2_9_9_1","unstructured":"AarsandA Fernandez\u2010CalleP WebsterC et\u00a0al.The EFLM biological variation database. Accessed January 2024.https:\/\/biologicalvariation.eu\/"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1532\/LH96.04068"},{"issue":"9","key":"e_1_2_9_11_1","first-page":"1503","article-title":"Performance of the XN\u20102000 WPC channel\u2010flagging to differentiate reactive and neoplastic leukocytosis","volume":"54","author":"Schuff\u2010Werner P","year":"2016","journal-title":"Clin Chem Lab Med"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.25017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T07:25:33Z","timestamp":1710573933000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.25017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/jcla.25017"],"URL":"https:\/\/doi.org\/10.1002\/jcla.25017","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"type":"print","value":"0887-8013"},{"type":"electronic","value":"1098-2825"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"2023-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e25017"}}