{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:29:52Z","timestamp":1790951392243,"version":"4.1.0"},"reference-count":86,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004847","name":"Zahedan University of Medical Sciences","doi-asserted-by":"publisher","award":["10656"],"award-info":[{"award-number":["10656"]}],"id":[{"id":"10.13039\/501100004847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Insulin resistance has been correlated with the genetic diversity within the insulin\u2010like binding proteins genes. Moreover, insulin resistance is one of the key characteristics of the widespread reproductive endocrine condition known as polycystic ovarian syndrome (PCOS). Hence, this study is aimed to determine the association between <jats:italic>IGFBP3<\/jats:italic> and <jats:italic>IGF2BP2<\/jats:italic> gene variants and PCOS risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 300 subjects (150 PCOS cases diagnosed based on Rotterdam ESHRE\/ASRM consensus criteria and 150 healthy subjects) were recruited in this case\u2013control cross\u2010sectional study. Tetra\u2010primer amplification refractory mutation system polymerase chain reaction (ARMS\u2010PCR) was used for genotyping rs11705701, whereas genotyping of rs1470579 and rs2854744 was done employing PCR\u2010restriction fragment length polymorphism (PCR\u2010RFLP) technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The CC and AA+AC genotypes of rs1470579 conferred an increased risk of PCOS in our population. Regarding the rs2854744, an increased risk of PCOS was observed under the codominant homozygous (TT vs. GG) model by 2.54 fold. The C allele of rs1470579 and T allele of rs2854744 enhanced PCOS risk by 1.97 and 1.46 folds, respectively. Haplotype analysis showed that the A<jats:sub>rs1470579<\/jats:sub>A<jats:sub>rs11705701<\/jats:sub> haplotype conferred a decreased risk of PCOS (odds ratio\u2009=\u20090.53, 95% confidence interval\u2009=\u20090.34\u20130.83, <jats:italic>p<\/jats:italic>\u2009=\u20090.006). The AC\/GG\/GT, AA\/GA\/GT, AC\/GA\/GG, and AC\/GA\/GT genotype combinations of rs1470579\/rs11705701\/rs2854744 were associated with a decreased risk of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>IGF2BP2<\/jats:italic> rs1470579 and <jats:italic>IGFBP3<\/jats:italic> rs2854744 enhanced PCOS susceptibility in a Southeastern Iranian population. Further investigation involving larger cohorts representing diverse ethnic backgrounds is needed to confirm the current findings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.25021","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T05:34:27Z","timestamp":1710221667000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["<i>IGF2BP2<\/i> and <i>IGFBP3<\/i> Genotypes, Haplotypes, and Genetic Models Studies in Polycystic Ovary Syndrome"],"prefix":"10.1002","volume":"38","author":[{"given":"Fatemeh","family":"Govahi\u00a0Kakhki","sequence":"first","affiliation":[{"name":"Department of Nutrition, School of Medicine Zahedan University of Medical Sciences  Zahedan 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