{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T02:53:16Z","timestamp":1777863196603,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515110921"],"award-info":[{"award-number":["2023A1515110921"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to indicate whether a declined plasma concentration of valproic acid (VPA) induced by co\u2010administration of meropenem (MEPM) could affect the antiepileptic efficacy of VPA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed data of hospitalized patients who were diagnosed with status epilepticus or epilepsy between 2010 and 2019. Patients co\u2010administered VPA and MEPM during hospitalization were screened and assigned to the exposure group, while those co\u2010administerd VPA and other broad\u2010spectrum antibiotics were allocated to the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The exposure group and control group included 50 and 11 patients, respectively. With a similar dosage of VPA, the plasma concentration of VPA significantly decreased during co\u2010administration (24.6\u2009\u00b1\u20094.3\u2009\u03bcg\/mL) compared with that before co\u2010administration (88.8\u2009\u00b1\u200913.6\u2009\u03bcg\/mL, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), and it was partly recovered with the termination of co\u2010administration (39.8\u2009\u00b1\u200913.2\u2009\u03bcg\/mL, <jats:italic>p<\/jats:italic>\u2009=\u20090.163) in the exposure group. The inverse probability of treatment weighting estimated the treatment efficacy via changes in seizure frequency, seizure duration, and concomitant use of antiepileptic drugs, which were not significantly different between the exposure and control groups. In the exposure group, there was no significant differences in seizure frequency between the periods of before\u2010during and before\u2010after (<jats:italic>p<\/jats:italic>\u2009=\u20090.074 and 0.153, respectively). Seizure duration during VPA\u2013MEPM co\u2010administration was not significantly different from that before co\u2010administration (<jats:italic>p<\/jats:italic>\u2009=\u20090.291).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this study, the reduced plasma concentration of VPA induced by the co\u2010administration of MEPM did not affect the antiepileptic efficacy of VPA. This conclusion should be interpreted with caution, and more research is warranted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>Chinese Clinical Trial Registry: ChiCTR2000034567. Registered on 10 July 2020<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.25025","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T15:12:35Z","timestamp":1712070755000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of a Declined Plasma Concentration of Valproic Acid Induced by Meropenem on the Antiepileptic Efficacy of Valproic Acid"],"prefix":"10.1002","volume":"38","author":[{"given":"Chunping","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Nanfang Hospital, Southern Medical University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of New Drug Design and Evaluation  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongfang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Neurology Department, Nanfang Hospital Southern Medical University  Guangzhou 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