{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:56:09Z","timestamp":1753869369885,"version":"3.41.2"},"reference-count":40,"publisher":"Wiley","issue":"19-20","license":[{"start":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:00:00Z","timestamp":1726704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005001","name":"Ahvaz Jundishapur University of Medical Sciences","doi-asserted-by":"publisher","award":["OG\u20109945"],"award-info":[{"award-number":["OG\u20109945"]}],"id":[{"id":"10.13039\/501100005001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Oral candidiasis (OC) is one of the most common mucosal infections in those afflicted with HIV\/AIDS. This study aimed to provide detailed information on the phenotype, genotype, antifungal susceptibility, and biofilm formation ability of oral <jats:italic>Candida albicans<\/jats:italic> isolated from HIV\u2010infected patients with OC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 25 <jats:italic>C. albicans<\/jats:italic> isolates were collected from oral lesions of HIV\u2010infected patients referred to Behavioral Diseases Counseling Center affiliated with Ahvaz Jundishapur University of Medical Sciences, Iran. The antifungal susceptibility testing was done according to CLSI M27 guideline (fourth edition). The crystal violet method was used to evaluate the biofilm formation ability of isolates. Different phenotypes were identified on yeast extract\u2010peptone\u2010dextrose agar medium supplemented with phloxine B. Genotyping analysis of the isolates was performed using high\u2010resolution melting (HRM) assays and ABC genotyping.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The highest and lowest susceptibility of the <jats:italic>C. albicans<\/jats:italic> isolates was found for fluconazole 24 (96%) and ITC 18 (72%), respectively. Forty\u2010eight percent of the isolates had high biofilm formation ability and exhibited gray cell type. The most common genotype was genotype B (52%). HRM analysis of HIS3, EF3, and CDC3 markers showed three, four, and five different groups, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Investigating the phenotype, antifungal susceptibility and biofilm formation ability of the <jats:italic>C. albicans<\/jats:italic> isolates obtained from oral lesions of HIV\u2010infected patients revealed that the dominant genotypes in the current research could cause more serious infections from the oral source. We recommend further research with a larger sample size to determine the molecular epidemiology of <jats:italic>C. albicans<\/jats:italic> among HIV patients in Iran.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.25103","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T14:03:15Z","timestamp":1726754595000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characteristics of <i>Candida albicans<\/i> Derived From <scp>HIV<\/scp>\u2010Positive Individuals With Oral Candidiasis: Genotyping, Phenotypic Variation, Antifungal Susceptibility, and Biofilm Formation"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1071-9257","authenticated-orcid":false,"given":"Maryam","family":"Erfaninejad","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences Shoushtar Faculty of Medical Sciences  Shoushtar Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5347-2082","authenticated-orcid":false,"given":"Ali\u00a0Zarei","family":"Mahmoudabadi","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Research Center, Health Research Institute Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"},{"name":"Department of Medical Mycology, School of Medicine Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8090-2332","authenticated-orcid":false,"given":"Mohammad","family":"Hashemzadeh","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Research Center, Health Research Institute Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"},{"name":"Department of Microbiology, School of Medicine Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3556-8838","authenticated-orcid":false,"given":"Elham","family":"Maraghi","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, School of Health Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6898-1309","authenticated-orcid":false,"given":"Mahnaz","family":"Fatahinia","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Research Center, Health Research Institute Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"},{"name":"Department of Medical Mycology, School of Medicine Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2167171"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c04189"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.983348"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.00980"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-13-13"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjm.2016.01.005"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.837536"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001830"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00043-16"},{"issue":"5","key":"e_1_2_12_11_1","first-page":"400","article-title":"ABC Genotyping and Putative Virulence Factors of Candida albicans Clinical Isolates","volume":"15","author":"Moron L.","year":"2019","journal-title":"Malaysian Journal of Microbiology"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jam.15006"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00122-008-0870-8"},{"key":"e_1_2_12_14_1","doi-asserted-by":"crossref","unstructured":"A.\u2010L.Meistertzheim I.Calves S.Artigaud et\u00a0al. 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