{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T17:39:15Z","timestamp":1781285955164,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","award":["69880999"],"award-info":[{"award-number":["69880999"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The management of multiple myeloma is challenging because the disease is incurable and unexpected relapses can threaten a patient's survival. Several assessment systems are currently available, but they often require invasive or costly procedures (e.g., instrumental bone marrow and whole\u2010body examinations) or rely on non\u2010specific markers in blood and urine that may not be sufficient to assess and monitor the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To address some of these limitations, the aim of this study was to evaluate the potential use of soluble B\u2010Cell Maturation Antigen (BCMA), a promising new serum biomarker, as a toll for moniting multiple myeloma patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials &amp; Methods<\/jats:title><jats:p>An unselected cohort of 57 newly diagnosed or relapsed myeloma patients was followed up for 6\u2009months after starting a new therapy. Soluble BCMA levels were measured in peripheral blood using a simple and inexpensive ELISA assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Soluble BCMA was detectable in peripheral blood by a simple and inexpensive assay in all patients, even in non\u2010secretory disease or during BCMA\u2010targeted therapies, and significant changes in its levels were observed over time. The analysis showed that the decrease in sBCMA at 1 and 6\u2009months reflects the quality of the clinical response to anti\u2010myeloma regimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion &amp; Conclusion<\/jats:title><jats:p>The data provide interesting insights into the usefulness of sBCMA as a non\u2010invasive tool\u00a0for early assessment of treatment efficacy. Its simple and cost\u2010effective detection in peripheral blood could provide clinicians with an addiotional resource for monitoring disease progression and tailoring treatment strategies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.25151","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T11:02:09Z","timestamp":1737025329000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Predictive Role of Soluble B\u2010Cell Maturation Antigen in Short\u2010Term Monitoring of Differently Treated Multiple Myeloma Patients: A Prospective Study"],"prefix":"10.1002","volume":"39","author":[{"given":"Laura","family":"Caponi","sequence":"first","affiliation":[{"name":"Clinical Pathology Laboratory, Pisa University Hospital, Department of Translational Research and New Technologies in Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4291-8875","authenticated-orcid":false,"given":"Maria Livia","family":"Del Giudice","sequence":"additional","affiliation":[{"name":"Hematology Division, Pisa University Hospital, Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Botti","sequence":"additional","affiliation":[{"name":"Clinical Pathology Laboratory, Pisa University Hospital, Department of Translational Research and New Technologies in Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Ursino","sequence":"additional","affiliation":[{"name":"Clinical Pathology Laboratory, Pisa University Hospital, Department of Translational Research and New Technologies in Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Gennari","sequence":"additional","affiliation":[{"name":"Clinical Pathology Laboratory, Pisa University Hospital, Department of Translational Research and New Technologies in Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo","family":"Paolicchi","sequence":"additional","affiliation":[{"name":"Clinical Pathology Laboratory, Pisa University Hospital, Department of Translational Research and New Technologies in Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Galimberti","sequence":"additional","affiliation":[{"name":"Hematology Division, Pisa University Hospital, Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Buda","sequence":"additional","affiliation":[{"name":"Hematology Division, Pisa University Hospital, Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010019\u20100435\u20107"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010022\u201001531\u20102"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262\u2010023\u201003559\u20104"},{"issue":"1","key":"e_1_2_9_6_1","first-page":"5","article-title":"The Paraprotein\u2013An Enduring Biomarker","volume":"40","author":"Tate J. 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