{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:20:11Z","timestamp":1790270411581,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The clinical utility of urinary red blood cell (RBC) distribution (URD) remains limited. This study aimed to compare the diagnostic performance of URD and dysmorphic RBC (dRBC) in a multicenter study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study enrolled 703 patients who visited four tertiary medical centers in Korea. Patients were classified into glomerular diseases with biopsy (<jats:italic>N<\/jats:italic>\u2009=\u2009169), renal diseases including chronic kidney disease (<jats:italic>N<\/jats:italic>\u2009=\u2009194), nephrotic syndrome (NS; <jats:italic>N<\/jats:italic>\u2009=\u200988), tubulointerstitial diseases (<jats:italic>N<\/jats:italic>\u2009=\u200936), acute kidney injury (<jats:italic>N<\/jats:italic>\u2009=\u200932), others (<jats:italic>N<\/jats:italic>\u2009=\u200910), and extrarenal diseases (<jats:italic>N<\/jats:italic>\u2009=\u2009174). Renal parameters, urine microscopic examination, urinalysis, and URD assessments were conducted. The diagnostic performances of dRBC and URD were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median values of both dRBC and URD were significantly elevated in patients with glomerular diseases. URD exhibited a significant correlation with dRBC (<jats:italic>r<\/jats:italic>\u2009=\u20090.536) and albumin creatinine ratio (<jats:italic>r<\/jats:italic>\u2009=\u20090.186), while no significant correlation was observed with specific gravity (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.03). Among renal diseases, dRBC and URD values were notably higher in patients with NS. The agreement rate between dRBC and URD results was 78.3% (112\/143), with 31 instances showing discrepancies. ROC curve analysis comparing glomerular and extrarenal diseases yielded cutoff values of 18% for dRBC and 31.9% for URD, resulting in corresponding areas under the curve (AUC) of 0.79 and 0.83, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>URD exhibited a comparable diagnostic performance, as indicated by a similar AUC value to that of dRBC, while offering the added advantage of providing objective and standardizable results. This attribute enhances its utility as a parameter for distinguishing between patients with glomerular hematuria (GH) and those with non\u2010GH.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.25159","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T10:20:21Z","timestamp":1738578021000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of Urinary Red Blood Cell Distribution (<scp>URD<\/scp>) and Dysmorphic Red Blood Cells for Detecting Glomerular Hematuria: A Multicenter Study"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8298-1652","authenticated-orcid":false,"given":"A\u2010Jin","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Daegu Catholic University Medical Center  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7854-3011","authenticated-orcid":false,"given":"Hae In","family":"Bang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Soonchunhyang University Seoul Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8438-3365","authenticated-orcid":false,"given":"Sun Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Pusan National University Yangsan Hospital  Yangsan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1983-2515","authenticated-orcid":false,"given":"Dongil","family":"Won","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Kyungpook National University Hospital  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7074-2665","authenticated-orcid":false,"given":"Myung Seo","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine CHA Bundang Medical Center  Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6453-7099","authenticated-orcid":false,"given":"Hyun\u2010ji","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Kosin University Gospel Hospital  Pusan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3562-7586","authenticated-orcid":false,"given":"In Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Daegu Catholic University School of Medicine  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7450-7117","authenticated-orcid":false,"given":"Chang\u2010Ho","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Daegu Catholic University Medical Center  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)92191-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.85a.17029"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)91715-1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000045446"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.10.3.252"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1963.tb05480.x"},{"key":"e_1_2_9_8_1","first-page":"566","article-title":"Erythrocyte Deformation in Ischemic Acute Tubular Necrosis and Amelioration by Splenectomy in the Dog","volume":"65","author":"Mandal A. 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