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It also explores innovative technologies that enhance detection accuracy, speed, and efficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nonstructural protein 1 (NS1) serves as a key biomarker present in high concentrations during the early stages of DENV infection, underscoring the need for timely detection. Traditional methods, while effective, have limitations that new technologies aim to address. Biosensors, particularly nanobiosensors, have emerged as promising tools for rapid, sensitive, and cost\u2010effective DENV detection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The adoption of advanced detection methods, especially nanobiosensors, is crucial for improving DENV management and reducing human suffering. This review provides a comprehensive overview of nanobiosensors and their applications, presented in an accessible manner for readers.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.70012","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T12:10:52Z","timestamp":1741867852000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Advances in Nanobiosensors for Rapid and Sensitive Detection of Dengue Virus Biomarkers by Using Clinical Laboratory"],"prefix":"10.1002","volume":"39","author":[{"given":"Seyedeh Niloufar","family":"Rajaei","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy Friedrich Schiller University Jena  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Darvish","sequence":"additional","affiliation":[{"name":"School of Aerospace and Subaquatic Medicine, Infectious Diseases &amp; Tropical Medicine Research Center(IDTMC) AJA University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Zare","sequence":"additional","affiliation":[{"name":"Shiraz University of Medical Sciences Faculty of Medicine  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamed","family":"Abdollahi","sequence":"additional","affiliation":[{"name":"Department of Parasitology, School of Medicine Ahvaz Jundishapur University of Medical Sciences  Ahvaz Khuzestan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahid","family":"Alivirdiloo","sequence":"additional","affiliation":[{"name":"Medical Doctor Department of Physiology and Pharmacology Mazandaran University of Medical Sciences  Ramsar Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mobasher","family":"Hajiabbasi","sequence":"additional","affiliation":[{"name":"Medical Doctor; Islamic Azad University of Tonekabon  Tonekabon Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhood","family":"Ghazi","sequence":"additional","affiliation":[{"name":"Clinical Research Development Unit of Tabriz Valiasr Hospital Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Mobed","sequence":"additional","affiliation":[{"name":"Social Determinants of Health Research Center Health Management and Safety Promotion  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3126\/ijasbt.v1i3.8384"},{"key":"e_1_2_12_3_1","first-page":"375","volume-title":"Yellow Fever and Dengue, Introduction to Clinical Infectious Diseases: A Problem\u2010Based Approach","author":"Fever R.\u2010O. 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